Effects of single-session versus multi-session non-invasive brain stimulation on craving and consumption in individuals with drug addiction, eating disorders or obesity: A meta-analysis
Effects of single-session versus multi-session non-invasive brain stimulation on craving and consumption in individuals with drug addiction, eating disorders or obesity: A meta-analysis
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单次与多次非侵入性脑刺激对吸毒成瘾、饮食失调或肥胖个体的渴望和消费的影响：一项荟萃分析
DOI：
10.1016/j.brs.2018.12.975
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发表时间：
2019-05
影响因子：
7.7
通讯作者：
Xiaolin Zhou
中科院分区：
文献类型：
--
作者：
Sensen Song;Anna Zilverst;Wenjun Gui;Hui-jie Li;Xiaolin Zhou
背景脑刺激干预越来越多地用于减少药物成瘾或过度饮食行为的个体的渴望和消费。然而，在这方面，这些新的治疗方法的有效性以及效果大小是否受到干预时间的影响尚未得到全面评估。采用荟萃分析方法评估针对背外侧前额叶皮层（dlPFC）的非侵入性兴奋性脑刺激[经颅直流电刺激（tDCS）和高频重复经颅磁刺激（rTMS）]的有效性减少渴望和消费水平的药物和饮食addictions.MethodsAfter一个全面的文献检索，48同行评议的研究（共1095名参与者），包括在当前的荟萃分析。我们计算对冲'sgas一个保守的措施，用于评估效果sizes.ResultsRandom效应分析显示，神经调节干预的渴望和消费的中等影响，有利于积极的假刺激的一个小的影响。这些影响在研究的不同人群（酒精、尼古丁、非法药物、饮食成瘾）或所使用的技术（rTMS/tDCS，左/右半球）之间没有差异。与单次治疗方案相比，多次治疗方案显示出更大的减少渴望和消费的效应量，治疗次数或给予脉冲与渴望减少之间存在正线性相关，结论我们的研究结果提供了令人信服的证据，即针对dlPFC的新型非侵入性脑刺激可以降低渴望和消费水平（为后一种药物成瘾效应提供了第一个元分析证据），与单次干预相比，多次干预的效果更大。
BackgroundBrain stimulation interventions are increasingly used to reduce craving and consumption in individuals with drug addiction or excessive eating behavior. However, the efficacy of these novel treatments and whether effect sizes are affected by the length of the intervention has not been comprehensively evaluated.ObjectiveA meta-analytical approach was employed to evaluate the effectiveness of non-invasive excitatory brain stimulation [transcranial Direct Current Stimulation (tDCS) and high-frequency repetitive Transcranial Magnetic Stimulation (rTMS)] targeted at dorsolateral prefrontal cortex (dlPFC) for reducing craving and consumption levels in drug and eating addiction, including both single- and multi-session protocols.MethodsAfter a comprehensive literature search, 48 peer-reviewed studies (1095 participants in total) were included in the current meta-analysis. We computed Hedge'sgas a conservative measure for evaluating effect sizes.ResultsRandom effects analyses revealed a small effect of neuromodulation interventions on craving and a medium effect on consumption, favoring active over sham stimulation. These effects did not differ across the different populations investigated (alcohol, nicotine, illicit drugs, eating addictions) or by the used technique (rTMS/tDCS, left/right hemisphere). Multi-session protocols showed a larger effect size for reducing craving and consumption than single-session protocols, with a positive linear association between the number of sessions or administered pulses and craving reduction, indicating a dose-response effect.ConclusionsOur results provide compelling evidence that novel non-invasive brain stimulation targeted at dlPFC reduces craving and consumption levels (providing the first meta-analytical evidence for the latter effect in drug addiction), with larger effects in multi-session as compared to single-session interventions.
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影响因子：
4.3
作者：
Sauvaget A;Trojak B;Bulteau S;Jiménez-Murcia S;Fernández-Aranda F;Wolz I;Menchón JM;Achab S;Vanelle JM;Grall-Bronnec M
通讯作者：
Grall-Bronnec M
DOI：
10.1176/appi.neuropsych.16080147
发表时间：
2017-03
期刊：
The Journal of neuropsychiatry and clinical neurosciences
影响因子：
--
作者：
B. Trojak;A. Sauvaget;S. Fecteau;L. Lalanne;J. Chauvet-Gelinier;S. Koch;S. Bulteau;D. Zullino;S. Achab
通讯作者：
B. Trojak;A. Sauvaget;S. Fecteau;L. Lalanne;J. Chauvet-Gelinier;S. Koch;S. Bulteau;D. Zullino;S. Achab
影响因子：
3.7
作者：
Herremans SC;Van Schuerbeek P;De Raedt R;Matthys F;Buyl R;De Mey J;Baeken C
通讯作者：
Baeken C
影响因子：
7.7
作者：
Peterchev, Angel V.;Wagner, Timothy A.;Miranda, Pedro C.;Nitsche, Michael A.;Paulus, Walter;Lisanby, Sarah H.;Pascual-Leone, Alvaro;Bikson, Marom
通讯作者：
Bikson, Marom
影响因子：
10.6
作者：
Kaye, Walter H.;Wierenga, Christina E.;Bailer, Ursula F.;Simmons, Alan N.;Wagner, Angela;Bischoff-Grethe, Amanda
通讯作者：
Bischoff-Grethe, Amanda