Does a shared neurobiology for foods and drugs of abuse contribute to extremes of food ingestion in anorexia and bulimia nervosa?
Does a shared neurobiology for foods and drugs of abuse contribute to extremes of food ingestion in anorexia and bulimia nervosa?
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DOI：
10.1016/j.biopsych.2013.01.002
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发表时间：
2013-05-01
影响因子：
10.6
通讯作者：
Bischoff-Grethe, Amanda
中科院分区：
文献类型：
--
作者：
Kaye, Walter H.;Wierenga, Christina E.;Bailer, Ursula F.;Simmons, Alan N.;Wagner, Angela;Bischoff-Grethe, Amanda
神经性厌食症（AN）的饥饿或神经性贪食症（BN）的暴饮暴食是一种成瘾形式吗？或者，为什么患有BN的人更容易受到伤害，而AN受到保护，不会滥用药物？这些问题是由最近的研究产生的，这些研究表明，滥用食物和药物的神经回路是重叠的。为了确定一个共同的神经生物学是否有助于饮食失调（EDs）和药物滥用，本综述集中在影像学研究中，研究了AN和BN对食物味道的反应和旨在表征奖励和行为抑制的任务。BN和那些有药物滥用障碍的人可能有相同的多巴胺D2受体相关的脆弱性，相反的发现可能有助于AN对药物滥用的“保护”。此外，成像研究提供了与AN异常抑制和自我控制以及BN抑制自我控制减弱相关的执行皮质纹状体过程的见解，这些过程可能影响美味食物的奖励方面和可能的其他圆满行为。AN和BN倾向于具有病态前特征，如完美主义和焦虑，这使他们容易采取极端的食物摄入来减少负面情绪状态。边缘和执行皮质纹状体回路内部和/或之间的失调是导致这些症状的原因。有限的数据支持奖励和抑制过程可能有助于ED和成瘾性障碍症状的假设，但就共享或独立过程而言，对这种机制的分子生物学知之甚少。
Is starvation in anorexia nervosa (AN) or overeating in bulimia nervosa (BN) a form of addiction? Alternatively, why are individuals with BN more vulnerable and AN protected from substance abuse? Such questions have been generated by recent studies that suggest that there are overlapping neural circuits for foods and drugs of abuse. In order to determine whether a shared neurobiology contributes to eating disorders (EDs) and substance abuse, this review focused on imaging studies that investigated response to tastes of food and tasks designed to characterize reward and behavioral inhibition in AN and BN. BN and those with substance abuse disorders may share dopamine D2 receptor related vulnerabilities, and opposite findings may contribute to “protection” from substance abuse in AN. Moreover, imaging studies provide insights into executive cortico-striatal processes related to extraordinary inhibition and self-control in AN and diminished inhibitory self-control in BN that may influence the rewarding aspect of palatable foods and likely other consummatory behaviors. AN and BN tend to have premorbid traits, such as perfectionism and anxiety that make them vulnerable to employing extremes of food ingestion which serve to reduce negative mood states. Dysregulation within and/or between limbic and executive cortio-striatal circuits contributes to such symptoms. Limited data support the hypothesis that reward and inhibitory processes may contribute to symptoms in ED and addictive disorders, but little is known about the molecular biology of such mechanisms in terms of shared or independent processes.
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影响因子：
2.3
作者：
Gabbay, FH
通讯作者：
Gabbay, FH
影响因子：
7.6
作者：
Besson, Morgane;Belin, David;Dalley, Jeffrey W.
通讯作者：
Dalley, Jeffrey W.
影响因子：
17.7
作者：
Anderluh, MB;Tchanturia, K;Treasure, J
通讯作者：
Treasure, J
影响因子：
10.6
作者：
Frank, GK;Bailer, UF;Kaye, WH
通讯作者：
Kaye, WH
DOI：
10.1007/978-1-61779-458-2_23
发表时间：
2012-01-01
期刊：
PSYCHIATRIC DISORDER: METHODS AND PROTOCOLS
影响因子：
--
作者：
Avena, Nicole M.;Bocarsly, Miriam E.;Hoebel, Bartley G.
通讯作者：
Hoebel, Bartley G.