Multi-omics signatures of the human early life exposome.
Multi-omics signatures of the human early life exposome.
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DOI：
10.1038/s41467-022-34422-2
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发表时间：
2022-11-21
影响因子：
16.6
通讯作者：
Vrijheid, Martine
中科院分区：
文献类型：
--
作者：
Maitre, Lea;Bustamante, Mariona;Hernandez-Ferrer, Carles;Thiel, Denise;Lau, Chung-Ho E.;Siskos, Alexandros;Vives-Usano, Marta;Ruiz-Arenas, Carlos;Pelegri-Siso, Dolors;Robinson, Oliver;Mason, Dan;Wright, John;Cadiou, Solene;Slama, Remy;Heude, Barbara;Casas, Maribel;Sunyer, Jordi;Papadopoulou, Eleni Z.;Gutzkow, Kristine B.;Andrusaityte, Sandra;Grazuleviciene, Regina;Vafeiadi, Marina;Chatzi, Leda;Sakhi, Amrit K.;Thomsen, Cathrine;Tamayo, Ibon;Nieuwenhuijsen, Mark;Urquiza, Jose;Borras, Eva;Sabido, Eduard;Quintela, Ines;Carracedo, Angel;Estivill, Xavier;Coen, Muireann;Gonzalez, Juan R.;Keun, Hector C.;Vrijheid, Martine
生命早期的环境暴露在生命过程的健康中发挥着至关重要的作用，但对环境对健康影响的分子表型知之甚少。在人类早期生活暴露体（HELIX）项目中，一个由1301对母子组成的多中心队列，我们将由妊娠和儿童期评估的>100种化学，户外，社会和生活方式暴露组成的个体暴露体与儿童期的多组学特征（甲基化组，转录组，蛋白质和代谢物）相关联。我们确定了1170个关联，249个在怀孕期间，921个在儿童时期，揭示了潜在的生物反应和暴露来源。妊娠期暴露，包括母亲吸烟、镉和钼，主要与儿童DNA甲基化变化有关。相比之下，儿童期暴露与所有组学层的特征相关，最常见的是血清代谢组，揭示了饮食，有毒化学化合物，必需微量元素和天气条件等的特征。我们全面而独特的所有协会资源（https：//helixomics.isglobal.org/）将有助于指导未来对早期生命周期的生物印记的研究。生命早期的环境暴露可能会对健康产生持久的影响，但其分子机制尚不清楚。在这里，作者发现了暴露因素与儿童多组学特征之间的1000多个关联，揭示了饮食，有毒化合物，必需微量元素和天气条件的特征。
Environmental exposures during early life play a critical role in life-course health, yet the molecular phenotypes underlying environmental effects on health are poorly understood. In the Human Early Life Exposome (HELIX) project, a multi-centre cohort of 1301 mother-child pairs, we associate individual exposomes consisting of >100 chemical, outdoor, social and lifestyle exposures assessed in pregnancy and childhood, with multi-omics profiles (methylome, transcriptome, proteins and metabolites) in childhood. We identify 1170 associations, 249 in pregnancy and 921 in childhood, which reveal potential biological responses and sources of exposure. Pregnancy exposures, including maternal smoking, cadmium and molybdenum, are predominantly associated with child DNA methylation changes. In contrast, childhood exposures are associated with features across all omics layers, most frequently the serum metabolome, revealing signatures for diet, toxic chemical compounds, essential trace elements, and weather conditions, among others. Our comprehensive and unique resource of all associations (https://helixomics.isglobal.org/) will serve to guide future investigation into the biological imprints of the early life exposome. Environmental exposures in early life can have lasting health effects, but the molecular mechanisms are not well understood. Here, the authors discover >1000 associations between exposure factors and child multi-omics profiles, revealing signatures for diet, toxic chemical compounds, essential trace elements, and weather conditions.
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DOI：
10.1038/nrendo.2016.186
发表时间：
2017-03
期刊：
Nature reviews. Endocrinology
影响因子：
--
作者：
Braun JM
通讯作者：
Braun JM
影响因子：
7.7
作者：
Floegel A;Stefan N;Yu Z;Mühlenbruch K;Drogan D;Joost HG;Fritsche A;Häring HU;Hrabě de Angelis M;Peters A;Roden M;Prehn C;Wang-Sattler R;Illig T;Schulze MB;Adamski J;Boeing H;Pischon T
通讯作者：
Pischon T
影响因子：
6.3
作者：
Cano-Sancho, German;Casas, Maribel
通讯作者：
Casas, Maribel
影响因子：
7.5
作者：
Chakinala, Raja Chandra;Khatri, Akshay;Gupta, Kriti;Koike, Kengo;Epelbaum, Oleg
通讯作者：
Epelbaum, Oleg
影响因子：
8.8
作者：
Gauglitz, Julia M.;Aceves, Christine M.;Dorrestein, Pieter C.
通讯作者：
Dorrestein, Pieter C.