Association between carotid atheroma and cerebral cortex structure at age 73 years.
Association between carotid atheroma and cerebral cortex structure at age 73 years.
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DOI：
10.1002/ana.25324
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发表时间：
2018-10
影响因子：
11.2
通讯作者：
Ducharme S
中科院分区：
文献类型：
--
作者：
Alhusaini S;Karama S;Nguyen TV;Thiel A;Bernhardt BC;Cox SR;Corley J;Taylor A;Evans AC;Star JM;Bastin ME;Wardlaw JM;Deary IJ;Ducharme S
研究颈动脉粥样硬化和大脑皮质厚度之间的关系，并调查皮质厚度是否介导颈动脉粥样硬化和相对认知能力下降之间的关联。我们评估了来自1936年洛锡安出生队列的554名社区居民受试者（男性/女性：296/258），他们在73岁时接受了脑磁共振成像和颈动脉多普勒超声研究。颈动脉粥样硬化标志物（颈内动脉狭窄、内膜-中层厚度、速度、脉动性和电阻率指数）与颅顶全脑皮质厚度之间的关系进行了横断面检查，控制了性别、广泛血管危险因素（VRF）和11岁时的智商（IQ-11）。我们还确定了73岁时颈动脉狭窄和液体智力综合指标之间的关系。应用中介模型来研究皮质厚度是否介导颈动脉狭窄和认知功能之间的关系。在73岁时，颈动脉狭窄（中位数= 15%）和大脑皮质厚度之间存在广泛的负相关性，与颈动脉狭窄侧、其他颈动脉测量、VRF和IQ-11无关。从轻度到重度颈动脉狭窄，这种关联在前循环和后循环区域几乎呈剂量-反应关系增加。颈动脉狭窄和液体智力之间也存在负相关（标准化β系数=-0.151，p = 0.001），这部分（约22%）是由颈动脉狭窄相关的大脑皮层变薄介导的。研究结果表明，颈动脉狭窄是加速大脑皮层和认知老化过程的标志，部分独立于可测量的VRF。前循环和后循环区域的皮质变薄部分介导了颈动脉粥样硬化和液体智力之间的关系。神经学年鉴2018; 84：576 - 587
To examine the relationship between carotid atherosclerosis and cerebral cortical thickness and investigate whether cortical thickness mediates the association between carotid atheroma and relative cognitive decline. We assessed 554 community‐dwelling subjects (male/female: 296/258) from the Lothian Birth Cohort 1936 who underwent brain magnetic resonance imaging and carotid Doppler ultrasound studies at age 73 years. The relationship between carotid atherosclerosis markers (internal carotid artery stenosis, intima–media thickness, velocity, pulsatility, and resistivity indexes) and vertex‐wide cerebral cortical thickness was examined cross‐sectionally, controlling for gender, extensive vascular risk factors (VRFs), and intelligence quotient at age 11 (IQ‐11). We also determined the association between carotid stenosis and a composite measure of fluid intelligence at age 73 years. A mediation model was applied to examine whether cortical thickness mediated the relationship between carotid stenosis and cognitive function. A widespread negative association was identified between carotid stenosis (median = 15%) and cerebral cortical thickness at age 73 years, independent of the side of carotid stenosis, other carotid measures, VRFs, and IQ‐11. This association increased in an almost dose–response relationship from mild to severe degrees of carotid stenosis, across the anterior and posterior circulation territories. A negative association was also noted between carotid stenosis and fluid intelligence (standardized beta coefficient = −0.151, p = 0.001), which appeared partly (approximately 22%) mediated by carotid stenosis‐related thinning of the cerebral cortex. The findings suggest that carotid stenosis represents a marker of processes that accelerate aging of the cerebral cortex and cognition that is in part independent of measurable VRFs. Cortical thinning within the anterior and posterior circulation territories partially mediated the relationship between carotid atheroma and fluid intelligence. Ann Neurol 2018;84:576–587
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影响因子：
5.7
作者：
Ducharme S;Albaugh MD;Nguyen TV;Hudziak JJ;Mateos-Pérez JM;Labbe A;Evans AC;Karama S;Brain Development Cooperative Group
通讯作者：
Brain Development Cooperative Group
影响因子：
4.1
作者：
Deary IJ;Gow AJ;Taylor MD;Corley J;Brett C;Wilson V;Campbell H;Whalley LJ;Visscher PM;Porteous DJ;Starr JM
通讯作者：
Starr JM
影响因子：
8.3
作者：
Zeki Al Hazzouri A;Vittinghoff E;Sidney S;Reis JP;Jacobs DR Jr;Yaffe K
通讯作者：
Yaffe K
影响因子：
11
作者：
Karama, S.;Bastin, M. E.;Murray, C.;Royle, N. A.;Penke, L.;Munoz Maniega, S.;Gow, A. J.;Corley, J.;Hernandez, Mdelc Valdes;Lewis, J. D.;Rousseau, M-E;Lepage, C.;Fonov, V.;Collins, D. L.;Booth, T.;Rioux, P.;Sherif, T.;Adalat, R.;Starr, J. M.;Evans, A. C.;Wardlaw, J. M.;Deary, I. J.
通讯作者：
Deary, I. J.
影响因子：
5.7
作者：
Deary, IJ;Simonotto, E;Wardlaw, JM
通讯作者：
Wardlaw, JM