Comparison of the elevated plus and elevated zero mazes in treated and untreated male Sprague-Dawley rats: effects of anxiolytic and anxiogenic agents.
Comparison of the elevated plus and elevated zero mazes in treated and untreated male Sprague-Dawley rats: effects of anxiolytic and anxiogenic agents.
复制标题
DOI：
10.1016/j.pbb.2010.09.013
复制
发表时间：
2011-01
影响因子：
3.6
通讯作者：
Williams, Michael T.
中科院分区：
文献类型：
--
作者：
Braun, Amanda A.;Skelton, Matthew R.;Vorhees, Charles V.;Williams, Michael T.
升高的正和零迷宫（分别为正和零）用于评估啮齿动物与焦虑相关的行为，但缺乏对大鼠的两种测试的直接比较。我们在成年雄性Sprague-Dawley大鼠中比较了两种方法。Zero组中未经处理的大鼠在开放区域停留的时间比Plus组长，头下垂的次数也比Plus组多，而Zero组的开始潜伏期和进入封闭区域的次数比Plus组低。地西泮（1mg /kg）暴露增加了两个迷宫的开放时间。约束（测试前60分钟）、育亨宾（2.5 mg/kg）和咖啡因（100 mg/kg）的效果相反，显著减少了在两个迷宫开放区域停留的时间。未处理的大鼠在两个迷宫中均未见行为上的性别二态性。虽然在Zero中未治疗的动物开放区域时间更长，但在药物刺激后，两个迷宫均检测到焦虑和焦虑作用。零迷宫数据不存在中心区，可以直接分析；否则，这两种方法出现可比性以下挑战。
The elevated plus and zero mazes (Plus and Zero, respectively) are used to assess behavior related to anxiety in rodents but direct comparisons of the two tests are lacking for rats. We compared the two methods in adult male Sprague-Dawley rats. Untreated rats in the Zero spent more time in open zones and exhibited more head dips than in the Plus whereas start latency and closed area entries were lower in the Zero than in the Plus. Diazepam (1 mg/kg) exposure increased time in the open in both mazes. Restraint (60 min prior to testing), yohimbine (2.5 mg/kg), and caffeine (100 mg/kg) had the opposite effect, significantly decreasing time spent in open zones in both mazes. No sexual dimorphism in behavior was seen in either maze in untreated rats. Although more open area time was evident in untreated animals in the Zero, after drug challenge both mazes detected anxiolytic and anxiogenic effects equally. Zero maze data can be analyzed directly because no center region exists; otherwise the two methods appear comparable following challenge.
登录
查看更多内容
影响因子：
3.6
作者：
Frye, C. A.;Paris, J. J.;Rhodes, M. E.
通讯作者：
Rhodes, M. E.
影响因子：
3.6
作者：
Hogg, S
通讯作者：
Hogg, S
影响因子：
2.9
作者：
JOHNSTON, AL;FILE, SE
通讯作者：
FILE, SE
影响因子：
2.7
作者：
Banna, Kelly M.;Back, Sudie E.;Do, Phong;See, Ronald E.
通讯作者：
See, Ronald E.
影响因子：
4.7
作者：
Jain, NS;Hirani, K;Chopde, CT
通讯作者：
Chopde, CT