Seizure epicenter depth and translaminar field potential synchrony underlie complex variations in tissue oxygenation during ictal initiation.
Seizure epicenter depth and translaminar field potential synchrony underlie complex variations in tissue oxygenation during ictal initiation.
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DOI：
10.1016/j.neuroimage.2017.12.088
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发表时间：
2018-05-01
期刊：
影响因子：
5.7
通讯作者：
Berwick J
中科院分区：
文献类型：
--
作者：
Harris SS;Boorman LW;Kennerley AJ;Sharp PS;Martin C;Redgrave P;Schwartz TH;Berwick J
癫痫活动期间的功能性充血是否足以满足此类事件的代谢需求尚存在争议。虽然一些研究已经证明了高氧发作期间，其他工作已经报道了短暂的缺氧发作，是空间依赖于局部表面微血管。至关重要的是，迄今为止尚未研究发作演变中的层差异如何影响随后的脑血管反应，并且考虑到可能的层依赖性神经血管机制和血管结构，这可能很重要。我们解决了这个悬而未决的问题，使用一种新的多模式的方法，使皮质组织的氧合，血流量和血红蛋白浓度的同时测量，以及神经活动的层状记录，在尿烷麻醉的大鼠模型的4-氨基吡啶诱导的反复发作。我们发现有一个紧密的关系，癫痫震中深度，translaminar局部场电位（LFP）同步性和组织氧合在复发性癫痫发作的早期阶段，其中深层癫痫发作与减少跨层同步性和长期缺氧，中层癫痫发作伴随着增加跨层同步性和高氧。通过与体感刺激和分级高碳酸血症的功能激活的比较，我们表明，这些脑血管相关的脑血管反应发生在保守的神经-血流动力学和血流量-容量耦合的存在下。我们的数据提供了新的见解层依赖性的癫痫相关的神经血管反应，这可能会调和不一致的观察癫痫相关的缺氧文献中，并强调一个潜在的层依赖性的脆弱性，可能有助于临床复发性癫痫发作的有害影响。我们的研究结果灌注相关的功能性神经影像学技术在癫痫的相关性进行了讨论。癫痫发作期间的层流LFP同步性影响组织氧合反应。深震中的癫痫发作与减少跨层同步。震中较深的癫痫发作与组织缺氧有关。尽管CBF增加和保守的神经-血流动力学耦合，仍观察到效果。提示在发作期间可能存在层状组织缺氧易感性。
Whether functional hyperemia during epileptic activity is adequate to meet the heightened metabolic demand of such events is controversial. Whereas some studies have demonstrated hyperoxia during ictal onsets, other work has reported transient hypoxic episodes that are spatially dependent on local surface microvasculature. Crucially, how laminar differences in ictal evolution can affect subsequent cerebrovascular responses has not been thus far investigated, and is likely significant in view of possible laminar-dependent neurovascular mechanisms and angioarchitecture. We addressed this open question using a novel multi-modal methodology enabling concurrent measurement of cortical tissue oxygenation, blood flow and hemoglobin concentration, alongside laminar recordings of neural activity, in a urethane anesthetized rat model of recurrent seizures induced by 4-aminopyridine. We reveal there to be a close relationship between seizure epicenter depth, translaminar local field potential (LFP) synchrony and tissue oxygenation during the early stages of recurrent seizures, whereby deep layer seizures are associated with decreased cross laminar synchrony and prolonged periods of hypoxia, and middle layer seizures are accompanied by increased cross-laminar synchrony and hyperoxia. Through comparison with functional activation by somatosensory stimulation and graded hypercapnia, we show that these seizure-related cerebrovascular responses occur in the presence of conserved neural-hemodynamic and blood flow-volume coupling. Our data provide new insights into the laminar dependency of seizure-related neurovascular responses, which may reconcile inconsistent observations of seizure-related hypoxia in the literature, and highlight a potential layer-dependent vulnerability that may contribute to the harmful effects of clinical recurrent seizures. The relevance of our findings to perfusion-related functional neuroimaging techniques in epilepsy are also discussed. Laminar LFP synchrony during seizures influences tissue oxygenation responses. Seizures with deep epicenters were associated with reduced cross-laminar synchrony. Seizures with deep epicenters were associated with tissue hypoxia. Effects observed despite increases in CBF and conserved neural-hemodynamic coupling. Suggests possible laminar susceptibility to tissue hypoxia during ictal events.
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影响因子：
5.7
作者：
Jones, M;Berwick, J;Mayhew, J
通讯作者：
Mayhew, J
影响因子：
25
作者：
Blinder, Pablo;Tsai, Philbert S.;Kaufhold, John P.;Knutsen, Per M.;Suhl, Harry;Kleinfeld, David
通讯作者：
Kleinfeld, David
影响因子：
5.6
作者：
Harris S;Boorman L;Bruyns-Haylett M;Kennerley A;Ma H;Zhao M;Overton PG;Schwartz TH;Berwick J
通讯作者：
Berwick J
DOI：
10.1038/jcbfm.2011.153
发表时间：
2012-02
期刊：
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
影响因子：
--
作者：
Jespersen SN;Østergaard L
通讯作者：
Østergaard L
DOI：
10.1111/j.1749-6632.1986.tb51254.x
发表时间：
1986-03-14
影响因子：
5.2
作者：
INGVAR, M
通讯作者：
INGVAR, M