The metastasis suppressor, N-myc downregulated gene 1 (NDRG1), is a prognostic biomarker for human colorectal cancer.
The metastasis suppressor, N-myc downregulated gene 1 (NDRG1), is a prognostic biomarker for human colorectal cancer.
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DOI：
10.1371/journal.pone.0068206
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Zheng M
中科院分区：
文献类型：
--
作者：
Mao Z;Sun J;Feng B;Ma J;Zang L;Dong F;Zhang D;Zheng M
转移仍然是导致结直肠癌患者长期生存不良的最常见原因之一。肿瘤转移抑制因子N-myc下调基因1(NDRG1)在多种癌症中的临床意义报道不一。在这项对240例结直肠癌临床标本的研究中，我们发现与配对的非肿瘤组织相比，NDRG1在大多数结直肠癌组织中的表达显著降低。统计学分析显示，NDRG1的表达与肿瘤分期、分化程度和转移呈显著负相关。与NDRG1阴性组相比，NDRG1阳性组5年随访无瘤生存率/总生存率较高(p = 0.000)。此外，NDRG1被认为是影响总生存率(p = 0.001)和复发(p = 0.003)的独立预后因素。我们的研究结论是，NDRG1是一种新的预测结直肠癌患者预后的新的有利指标。
Metastasis remains to be one of the most prevalent causes leading to poor long-term survival of colorectal cancer (CRC) patients. The clinical significances of tumor metastatic suppressor, N-myc downregulated gene 1 (NDRG1), have been inconsistently reported in a variety of cancerous diseases. In this study with 240 CRC clinical specimens, we showed that NDRG1 expression was significantly decreased in most of CRC tissues compared to the paired non-tumor counterparts. Statistical analysis revealed a significant inverse correlation of NDRG1 expression with tumor stage, differentiation status and metastasis. Compared with NDRG1-negative group, NDRG1-positve group had better disease-free/overall survival (p = 0.000) over 5 years’ follow-up. Furthermore, NDRG1 was considered to be an independent prognostic factor for overall survival (p = 0.001) and recurrence (p = 0.003). Our study concludes that NDRG1 is a novel favorable predictor for the prognosis in CRC patients.
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影响因子：
3.7
作者：
Bao B;Ali S;Ahmad A;Azmi AS;Li Y;Banerjee S;Kong D;Sethi S;Aboukameel A;Padhye SB;Sarkar FH
通讯作者：
Sarkar FH
影响因子：
2.6
作者：
Ando, T.;Ishiguro, H.;Kuwabara, Y.
通讯作者：
Kuwabara, Y.
影响因子：
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作者：
Lerner A;Grafi-Cohen M;Napso T;Azzam N;Fares F
通讯作者：
Fares F
影响因子：
11.2
作者：
Maruyama, Yuichiro;Ono, Mayumi;Kuwano, Michihiko
通讯作者：
Kuwano, Michihiko
影响因子：
2
作者：
Smallbone, K;Gavaghan, DJ;Maini, PK
通讯作者：
Maini, PK