Electrical Stimulation to Enhance Wound Healing.
Electrical Stimulation to Enhance Wound Healing.
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DOI：
10.3390/jfb12020040
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发表时间：
2021-06-19
影响因子：
4.8
通讯作者：
Hardy JG
中科院分区：
文献类型：
--
作者：
Rajendran SB;Challen K;Wright KL;Hardy JG
电刺激（ES）可以用作加速伤口愈合的治疗方式，特别是由于潜在病理学的并发症而具有受损愈合的慢性伤口。本文综述了ES如何影响伤口愈合的细胞机制，以及其在治疗急性和慢性伤口中的有效性。使用科克伦图书馆、Medline、Web of Science、Google Scholar和PubMed数据库进行了无出版日期限制的文献检索，30篇全文文章符合纳入标准。研究ES对愈合的一般机制的影响的体外和体内实验表明，伤口周围的上皮形成、成纤维细胞迁移和血管分布增加。六项体外研究证明了暴露于交流和脉冲电流后的杀菌作用。12项随机对照试验（RCT）研究了脉冲电流对慢性伤口愈合的影响。与对照组相比，所有审查的RCT均显示伤口尺寸缩小幅度更大，愈合率增加。总之，ES治疗有助于改善慢性伤口愈合，并可能减少与伤口管理相关的经济负担。然而，研究中使用的伤口特征、患者人口统计学和ES参数的变化为未来的系统性RCT研究提供了机会。
Electrical stimulation (ES) can serve as a therapeutic modality accelerating the healing of wounds, particularly chronic wounds which have impaired healing due to complications from underlying pathology. This review explores how ES affects the cellular mechanisms of wound healing, and its effectiveness in treating acute and chronic wounds. Literature searches with no publication date restrictions were conducted using the Cochrane Library, Medline, Web of Science, Google Scholar and PubMed databases, and 30 full-text articles met the inclusion criteria. In vitro and in vivo experiments investigating the effect of ES on the general mechanisms of healing demonstrated increased epithelialization, fibroblast migration, and vascularity around wounds. Six in vitro studies demonstrated bactericidal effects upon exposure to alternating and pulsed current. Twelve randomized controlled trials (RCTs) investigated the effect of pulsed current on chronic wound healing. All reviewed RCTs demonstrated a larger reduction in wound size and increased healing rate when compared to control groups. In conclusion, ES therapy can contribute to improved chronic wound healing and potentially reduce the financial burden associated with wound management. However, the variations in the wound characteristics, patient demographics, and ES parameters used across studies present opportunities for systematic RCT studies in the future.
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