An examination of the relationship among plasma brain derived neurotropic factor, peripheral vascular function, and body composition with cognition in midlife African Americans/Black individuals.
An examination of the relationship among plasma brain derived neurotropic factor, peripheral vascular function, and body composition with cognition in midlife African Americans/Black individuals.
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DOI：
10.3389/fnagi.2022.980561
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发表时间：
2022
影响因子：
4.8
通讯作者：
中科院分区：
文献类型：
--
作者：
尽管非裔美国人/黑人表现出与神经退行性变的发作和严重程度相关的较高风险因素，但仍被排除在几项著名的神经科学研究之外。因此，当前研究的目的是检查中年非裔美国人/黑人样本中脑源性神经营养因子 (BDNF)、外周血管功能和身体成分与认知之间的潜在关系。中年成年人（男性：n = 3, 60 ± 4 岁；女性：n = 9, 58 ± 5 岁）被邀请完成两次基线访视，间隔 4 周。通过静脉阻塞体积描记法测定外周血管功能，使用双能X射线吸收测定法测定身体成分，并收集血浆以量化BDNF水平。基于计算机的中枢神经系统生命体征测试用于提供众多认知领域的分数。主要结果包括复杂注意力 (r = 0.629) 和处理速度 (r = 0.734) 与血浆 BDNF 值显着相关 (p < 0.05)。然而，任何血管测量值与任何认知域或 BDNF 值之间均不存在显着（p > 0.05）关系。次要发现包括去脂体重和峰值充血 (r = 0.758) 以及总充血 (r = 0.855) 之间的关系。从这些结果得出的主要结论是，未来的临床试验有理由使用针对增加 BDNF 的干预措施来潜在地改善认知。此外，这些结果强烈表明，旨在通过改善已知的血管功能危险因素来改善认知健康的临床医生应该考虑能够促进骨骼肌大小和功能的干预措施，特别是在非裔美国人/黑人群体中。
African American/Black individuals have been excluded from several lines of prominent neuroscience research, despite exhibiting disproportionately higher risk factors associated with the onset and magnitude of neurodegeneration. Therefore, the objective of the current investigation was to examine potential relationships among brain derived neurotropic factor (BDNF), peripheral vascular function, and body composition with cognition in a sample of midlife, African American/Black individuals. Midlife adults (men: n = 3, 60 ± 4 years; women: n = 9, 58 ± 5 years) were invited to complete two baseline visits separated by 4 weeks. Peripheral vascular function was determined by venous occlusion plethysmography, a dual-energy X-ray absorptiometry was used to determine body composition, and plasma was collected to quantify BDNF levels. The CNS Vital Signs computer-based test was used to provide scores on numerous cognitive domains. The principal results included that complex attention (r = 0.629) and processing speed (r = 0.734) were significantly (p < 0.05) related to the plasma BDNF values. However, there was no significant (p > 0.05) relationship between any vascular measure and any cognitive domain or BDNF value. Secondary findings included the relationship between lean mass and peak hyperemia (r = 0.758) as well as total hyperemia (r = 0.855). The major conclusion derived from these results was that there is rationale for future clinical trials to use interventions targeting increasing BDNF to potentially improve cognition. Additionally, these results strongly suggest that clinicians aiming to improve cognitive health via improvements in the known risk factor of vascular function should consider interventions capable of promoting the size and function of skeletal muscle, especially in the African American/Black population.
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影响因子：
37.8
作者：
Churchwell, Keith;Elkind, Mitchell S. V.;Williams, Olajide
通讯作者：
Williams, Olajide
DOI：
10.1016/j.jalz.2017.11.002
发表时间：
2018-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
González HM;Tarraf W;Harrison K;Windham BG;Tingle J;Alonso A;Griswold M;Heiss G;Knopman D;Mosley TH
通讯作者：
Mosley TH
影响因子：
16.6
作者：
Iturria-Medina Y;Sotero RC;Toussaint PJ;Mateos-Pérez JM;Evans AC;Alzheimer’s Disease Neuroimaging Initiative
通讯作者：
Alzheimer’s Disease Neuroimaging Initiative
影响因子：
3
作者：
通讯作者：
--
非裔美国人个体中的阿尔茨海默氏病：发病率增加还是没有足够的数据？
DOI：
10.1038/s41582-021-00589-3
发表时间：
2022-01
期刊：
Nature reviews. Neurology
影响因子：
--
作者：
Barnes LL
通讯作者：
Barnes LL