Cerebrovascular function and its association with systemic artery function and stiffness in older adults with and without mild cognitive impairment.
Cerebrovascular function and its association with systemic artery function and stiffness in older adults with and without mild cognitive impairment.
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DOI：
10.1007/s00421-022-04956-w
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发表时间：
2022-08
影响因子：
3
通讯作者：
中科院分区：
文献类型：
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我们的目的是比较有和没有轻度认知障碍（MCI）的老年人的脑血管和全身血管功能，并确定哪些血管功能指标最能预测MCI的存在。在41例MCI患者和33例非MCI患者（对照组）中，我们比较了静息时大脑中动脉血流速度（MCAv）和脑血管搏动指数（PI）、脑血管对CO2的反应性以及对血压变化的反应性（% MCAv/%MAP）。通过血流介导的舒张功能（FMD）和脉搏波传导速度（PWV）评估全身血管功能。MCI组的脑血管PI高于对照组（平均值± SD：1.17 ± 0.27 vs. 1.04 ± 0.21），MCI组的%MCA v/%MAP较低（1.26 ± 0.44 vs. 1.50 ± 0.55%）。MCI组和对照组之间对CO2的绝对（p = 0.76）和相对脑血管反应性（p = 0.34）相似。当年龄作为协变量时，组间脑PI的显著差异消失。与对照组相比，MCI组PWV较高（13.2 ± 2.2 vs. 11.3 ± 2.5 m s-1），FMD%较低（4.41 ± 1.70 vs. 5.43 ± 2.15%）。FMD%与整个队列的PI呈正相关。Logistic回归分析表明，FMD和PWV显着区分MCI和对照组，独立于年龄，而纳入脑血管措施并没有提高模型的预测准确性。这些发现提出了全身血管硬度和内皮功能的早期变化可能有助于改变脑血管血流动力学和认知功能受损的可能性，并为MCI患者的预防和治疗策略提供了潜在的目标。在线版本包含补充材料，可通过10.1007/s 00421 -022-04956-w获得。
Our aim was to compare cerebrovascular and systemic vascular function between older adults with and without mild cognitive impairment (MCI), and to determine which measures of vascular function best predict the presence of MCI. In 41 adults with MCI and 33 adults without MCI (control) we compared middle cerebral artery velocity (MCAv) and cerebrovascular pulsatility index (PI) at rest, cerebrovascular reactivity to CO2, and responsiveness to changes in blood pressure (%∆MCAv/%∆MAP). Systemic vascular function was assessed by flow-mediated dilation (FMD) and stiffness by pulse wave velocity (PWV). Cerebrovascular PI was higher in MCI compared with control (mean ± SD: 1.17 ± 0.27 vs. 1.04 ± 0.21), and MCI exhibited a lower %∆MCAv/%∆MAP (1.26 ± 0.44 vs. 1.50 ± 0.55%). Absolute (p = 0.76) and relative cerebrovascular reactivity to CO2 (p = 0.34) was similar between MCI and control. When age was included as a covariate the significant difference in cerebral PI between groups was lost. PWV was higher (13.2 ± 2.2 vs. 11.3 ± 2.5 m s−1) and FMD% (4.41 ± 1.70 vs. 5.43 ± 2.15%) was lower in MCI compared with control. FMD% was positively associated with PI across the cohort. Logistic regression analysis indicated that FMD and PWV significantly discriminated between MCI and controls, independent of age, whereas the inclusion of cerebrovascular measures did not improve the predictive accuracy of the model. These findings raise the possibility that early changes in systemic vascular stiffness and endothelial function may contribute to altered cerebrovascular haemodynamics and impaired cognitive function, and present potential targets for prevention and treatment strategies in people with MCI. The online version contains supplementary material available at 10.1007/s00421-022-04956-w.
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影响因子：
4.1
作者：
Devenney KE;Sanders ML;Lawlor B;Olde Rikkert MGM;Schneider S;NeuroExercise Study Group
通讯作者：
NeuroExercise Study Group
DOI：
10.1152/ajpheart.00790.2016
发表时间：
2017-04-01
影响因子：
4.8
作者：
Brassard, Patrice;Ferland-Dutil, Helene;Ainslie, Philip N.
通讯作者：
Ainslie, Philip N.
影响因子：
8.3
作者：
Carter, Howard H.;Atkinson, Ceri L.;Green, Daniel J.
通讯作者：
Green, Daniel J.
影响因子：
2.5
作者：
Fleysher, Roman;Lipton, Michael L.;Derby, Carol A.
通讯作者：
Derby, Carol A.
影响因子：
5.6
作者：
Csipo, Tamas;Lipecz, Agnes;Yabluchanskiy, Andriy
通讯作者：
Yabluchanskiy, Andriy