Patent filarial infection modulates malaria-specific type 1 cytokine responses in an IL-10-dependent manner in a filaria/malaria-coinfected population.
Patent filarial infection modulates malaria-specific type 1 cytokine responses in an IL-10-dependent manner in a filaria/malaria-coinfected population.
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专利性丝状感染以IL-10依赖性方式调节疟疾特异性1型细胞因子反应，以丝状/疟疾菌感染的种群调节。
DOI：
10.4049/jimmunol.0900257
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发表时间：
2009-07-15
期刊：
影响因子：
--
通讯作者：
Nutman TB
中科院分区：
文献类型：
--
作者：
Metenou S;Dembélé B;Konate S;Dolo H;Coulibaly SY;Coulibaly YI;Diallo AA;Soumaoro L;Coulibaly ME;Sanogo D;Doumbia SS;Wagner M;Traoré SF;Klion A;Mahanty S;Nutman TB
The effect of filarial infections on malaria-specific immune responses was investigated in Malian villages co-endemic for filariasis and malaria. Cytokines were measured from plasma and Ag-stimulated whole blood from individuals with Wuchereria bancrofti (Wb) and/or Mansonella perstans (Mp) infections (Fil+; n = 19) and those without evidence of filarial infection (Fil−; n = 19). Plasma levels of IL-10 (geometric mean [GM] 22.8 vs. 10.4) were higher in Fil+ compared with Fil−, whereas levels of IP-10 were lower in Fil+ (GM = 66.3 vs. 110.0). Fil+ had higher levels of spontaneously secreted IL-10 (59.3 vs. 6.8 pg/ml) and lower levels of IL-2 (1.0 vs. 1.2 pg/ml) than did Fil−. Although there were no differences in levels of Staphylococcus aureus enterotoxin B-induced cytokines between the two groups, Fil+ mounted a lower IL-12p70 (1.11 vs. 3.83 pg/ml; p = 0.007), IFN-γ (5.44 vs. 23.41 pg/ml; p = 0.009), and IP-10 (29.43 vs. 281.7 pg/ml; p = 0.007) response following malaria Ag (MalAg) stimulation compared with Fil−. In contrast, Fil+ had a higher MalAg-specific IL-10 response (7318 pg/ml vs. 3029 pg/ml; p = 0.006) compared with those without filarial infection. Neutralizing Ab to IL-10 (but not to TGFβ) reversed the downregulated MalAg-specific IFN-γ and IP-10 (p < 0.001) responses in Fil+. Together these data demonstrate that filarial infections modulate the Plasmodium falciparum-specific IL-12p70/IFN-γ secretion pathways known to play a key role in resistance to malaria and thata they do so in an IL-10-dependent manner.
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影响因子：
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作者：
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通讯作者：
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DOI：
10.4269/ajtmh.1991.45.65
发表时间：
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发表时间：
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