Bat rabies in Washington State: Temporal-spatial trends and risk factors for zoonotic transmission (2000-2017).
Bat rabies in Washington State: Temporal-spatial trends and risk factors for zoonotic transmission (2000-2017).
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DOI：
10.1371/journal.pone.0205069
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Goldoft M
中科院分区：
文献类型：
--
作者：
Bonwitt J;Oltean H;Lang M;Kelly RM;Goldoft M
狂犬病是一种人畜共患的病毒性疾病，可以影响所有哺乳动物。在美国，大多数人类狂犬病病例是由蝙蝠引起的，蝙蝠是华盛顿州唯一已知的狂犬病病毒（RABV）宿主。我们试图描述蝙蝠RABV流行病学在华盛顿之间的蝙蝠RABV检测公众提交。我们研究了2006-2017年期间提交给诊断实验室的分类鉴定蝙蝠的RABV阳性率（阳性%）的时间和空间趋势。对于鼠耳蝠属物种的一个子集，我们评估了敏感性和预测值阳性（PPV）的形态识别键，使用线粒体标记物（细胞色素B）作为参考。对于2000-2016年期间测试的蝙蝠，我们通过与人类，猫和狗接触的情况分析了RABV阳性。在2006-2017年期间，所有蝙蝠物种的RABV阳性率为6.0%（176/2，928）。在≥100份标本中，RABV阳性率为2.0%~ 11.7%，以大棕蝠（Eptesicus fuscus）最高。每年的积极性增加的趋势是显着的，只有大棕蝙蝠（P = 0.02），并与一个地理集群的情况。形态鉴别检索表的敏感性和PPV值较高。evotis，而M. lucifugus，M. californicus，M. yumanensis和M. septentrionalis。阳性RABV结果与非人类物种、异常行为、异常隐藏、伤害、咬伤、在水体中发现、活着发现、在户外发现和被狗抓住显著相关。监测被动RABV监测趋势使公共卫生当局能够进行更准确的风险评估。蝙蝠物种的RABV阳性的时间和空间趋势的差异表明收集分类数据的重要性，虽然形态鉴定可能是不可靠的某些鼠耳蝠物种。应维持目前RABV暴露的公共卫生做法，因为如果没有诊断测试，蝙蝠中的RABV感染永远不能排除。
Rabies is a zoonotic viral disease that can affect all mammals. In the United States, the majority of human rabies cases are caused by bats, which are the only known reservoirs for rabies virus (RABV) in Washington State. We sought to characterize bat RABV epidemiology in Washington among bats submitted by the public for RABV testing. We examined temporal and spatial trends in RABV positivity (% positive) for taxonomically identified bats submitted to diagnostic laboratories during 2006–2017. For a subset of Myotis species, we evaluated sensitivity and predictive value positive (PPV) of morphological identification keys, using mitochondrial markers (cytochrome b) as a reference. For bats tested during 2000–2016, we analyzed RABV positivity by circumstances of encounters with humans, cats, and dogs. During 2006–2017, RABV positivity for all bat species was 6.0% (176/2,928). Among species with ≥100 submissions, RABV positivity was 2.0%–11.7% and highest among big brown bats (Eptesicus fuscus). An increasing trend in annual positivity was significant only for big brown bats (P = 0.02), and was circumstantially linked to a geographic cluster. Sensitivity and PPV of morphological identification keys was high for M. evotis but varied for M. lucifugus, M. californicus, M. yumanensis, and M. septentrionalis. A positive RABV result was significantly associated with nonsynanthropic species, abnormal behavior, abnormal hiding, injury, biting, found in a body of water, found alive, found outdoors, and caught by a dog. Monitoring passive RABV surveillance trends enables public health authorities to perform more accurate risk assessments. Differences in temporal and spatial trends in RABV positivity by bat species indicate the importance of collecting taxonomic data, although morphological identification can be unreliable for certain Myotis species. Current public health practices for RABV exposures should be maintained as RABV infection in bats can never be excluded without diagnostic testing.
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影响因子：
1.7
作者：
Lausen, CL;Barclay, RMR
通讯作者：
Barclay, RMR
DOI：
10.2460/javma.250.10.1117
发表时间：
2017-05-15
影响因子：
1.9
作者：
Birhane, Meseret G.;Cleaton, Julie M.;Wallace, Ryan M.
通讯作者：
Wallace, Ryan M.
影响因子：
10.7
作者：
Kumar, Sudhir;Stecher, Glen;Tamura, Koichiro
通讯作者：
Tamura, Koichiro
DOI：
10.1898/1051-1733(2007)88
发表时间：
2007-09-01
期刊：
Northwestern Naturalist
影响因子：
--
作者：
Farmer, Christopher J.;Kirchhoff, Matthew D.
通讯作者：
Kirchhoff, Matthew D.
DOI：
10.1093/bioinformatics/bts199
发表时间：
2012-06-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Kearse M;Moir R;Wilson A;Stones-Havas S;Cheung M;Sturrock S;Buxton S;Cooper A;Markowitz S;Duran C;Thierer T;Ashton B;Meintjes P;Drummond A
通讯作者：
Drummond A