Cancer-promoting effects of microbial dysbiosis.
Cancer-promoting effects of microbial dysbiosis.
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DOI：
10.1007/s11912-014-0406-0
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发表时间：
2014-10
影响因子：
4.7
通讯作者：
Weir, Tiffany L.
中科院分区：
文献类型：
--
作者：
Sheflin, Amy M.;Whitney, Alyssa K.;Weir, Tiffany L.
人类依赖于我们的肠道细菌的营养，免疫调节和代谢的贡献，以维持健康。然而，这种生物群落存在于谨慎的平衡中，如果被破坏，就会进入生态失调;这已被证明有助于结肠癌、胃癌、食管癌、胰腺癌、喉癌、乳腺癌和胆囊癌的病因学。这种病因学与宿主炎症密切相关，宿主炎症导致微生物生态失调并因微生物生态失调而加重，同时增加对病原体的脆弱性。测序技术的进步提高了我们对与全身各种癌症类型相关的微生物物种进行编目的能力。然而，将微生物生物标志物定义为癌症预测因子存在多种挑战，并且现有的识别癌症相关细菌的研究报告了不一致的结果。结合代谢物和微生物组分析可以帮助阐明肠道微生物群，代谢和宿主之间的相互作用。最终，了解肠道生态失调如何影响宿主反应和炎症对于准确了解微生物组在癌症中的作用至关重要。
Humans depend upon our commensal bacteria for nutritive, immune-modulating and metabolic contributions to maintenance of health. However, this commensal community exists in careful balance that, if disrupted, enters dysbiosis; which has been shown to contribute to the etiology of colon, gastric, esophageal, pancreatic, laryngeal, breast and gallbladder carcinomas. This etiology is closely tied to host inflammation, which causes and is aggravated by microbial dysbiosis while increasing vulnerability to pathogens. Advances in sequencing technology have increased our ability to catalog microbial species associated with various cancer types across the body. However, defining microbial biomarkers as cancer predictors presents multiple challenges and existing studies identifying cancer-associated bacteria have reported inconsistent outcomes. Combining metabolites and microbiome analyses can help elucidate interactions between gut microbiota, metabolism and the host. Ultimately, understanding how gut dysbiosis impacts host response and inflammation will be critical to creating an accurate picture of the role of the microbiome in cancer.
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