Inverse association between carbohydrate consumption and plasma adropin concentrations in humans.
Inverse association between carbohydrate consumption and plasma adropin concentrations in humans.
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DOI：
10.1002/oby.21557
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发表时间：
2016-08
期刊：
影响因子：
6.9
通讯作者：
Butler, Andrew A.
中科院分区：
文献类型：
--
作者：
Stevens, Joseph R.;Kearney, Monica L.;St-Onge, Marie-Pierre;Stanhope, Kimber L.;Havel, Peter J.;Kanaley, Jill A.;Thyfault, John P.;Weiss, Edward P.;Butler, Andrew A.
The role of metabolic condition and diet in regulating circulating levels of adropin, a peptide hormone linked to cardiometabolic control, is not well understood. Here we examined weight loss and diet effects on plasma adropin concentrations. The present report includes data from (1) a weight loss trial, (2) an evaluation of acute exercise effects on mixed-meal tolerance test responses, and (3) a meta-analysis to determine normal fasting adropin concentrations. Plasma adropin concentrations exhibit a distribution with positive skew and kurtosis. The effect of weight loss on plasma adropin concentrations was dependent on baseline plasma adropin concentrations, with an inverse association between baseline and a decline in concentrations after weight loss (Spearman’s ρ=−0.575; P<0.001). When ranked by baseline plasma adropin concentrations, only values in the upper quartile declined with weight loss. Plasma adropin concentrations under the bell-curve correlated negatively with habitual carbohydrate intake and plasma lipids. There was a negative correlation between baseline values and a transient decline in plasma adropin during the MMTT Plasma adropin concentrations in humans are sensitive to dietary macronutrients, perhaps due to habitual consumption of carbohydrate-rich diets suppressing circulating levels. Very high adropin levels may indicate cardiometabolic conditions sensitive to weight loss.
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影响因子：
29
作者：
Kumar KG;Trevaskis JL;Lam DD;Sutton GM;Koza RA;Chouljenko VN;Kousoulas KG;Rogers PM;Kesterson RA;Thearle M;Ferrante AW Jr;Mynatt RL;Burris TP;Dong JZ;Halem HA;Culler MD;Heisler LK;Stephens JM;Butler AA
通讯作者：
Butler AA
影响因子：
3
作者：
Nyhoff LM;Heden TD;Leidy HJ;Winn NC;Park YM;Thyfault JP;Kanaley JA
通讯作者：
Kanaley JA
小儿阻塞性睡眠呼吸暂停中循环的adropin浓度：与内皮功能的潜在相关性。
DOI：
10.1016/j.jpeds.2013.05.040
发表时间：
2013-10
期刊：
The Journal of pediatrics
影响因子：
--
作者：
Gozal D;Kheirandish-Gozal L;Bhattacharjee R;Molero-Ramirez H;Tan HL;Bandla HP
通讯作者：
Bandla HP
影响因子：
3.6
作者：
Poslusna, Kamila;Ruprich, Jiri;van't Veer, Pieter
通讯作者：
van't Veer, Pieter
影响因子：
2.4
作者：
Celik, Ebru;Yilmaz, Ercan;Aydin, Suleyman
通讯作者：
Aydin, Suleyman