Fentanyl-contaminated drugs and non-fatal overdose among people who inject drugs in Baltimore, MD.
Fentanyl-contaminated drugs and non-fatal overdose among people who inject drugs in Baltimore, MD.
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DOI：
10.1186/s12954-018-0240-z
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发表时间：
2018-07-05
影响因子：
4.4
通讯作者：
Sherman SG
中科院分区：
文献类型：
--
作者：
Park JN;Weir BW;Allen ST;Chaulk P;Sherman SG
阿片类药物危机在美国和其他地方仍然是一个重大的公共卫生问题。尽管全国芬太尼相关死亡率迅速上升，但人们对芬太尼在吸毒者发生非致命性过量服药中所起的作用知之甚少。我们检查了注射器服务计划(SSP)客户中非致命性过量用药和感知芬太尼暴露的流行率，并对非致命性过量用药的相关性进行了建模。数据来自2016年在马里兰州巴尔的摩招募的203名SSP客户的横断面调查。使用Logistic回归模型确定在过去12个月中经历非致命性过量服药的相关因素。大多数(65%)是男性，52%是黑人，41%是白人，37%是无家可归者。几乎所有人(97%)都使用海洛因，%的人使用可卡因(即快球)注射海洛因，许多人使用其他类型的毒品。一半(53%)的人认为他们的药物中存在芬太尼的一半、大部分或全部时间。终身和过去12个月非致命性过量的患病率分别为58%和31%。在过去12个月中，非致命性过量用药的独立相关因素是：超过一半的时间在药物中使用芬太尼(AOR = 2.79；95%CI = 1.00-4.68)、快速球注射(AOR = 2.80，95%CI = 1.26-6.23)、非处方药丁丙诺啡使用(AOR = 6.37；95%CI = 2.86-14.17)和无家可归(AOR = 3.07；95%CI = 1.28-7.39)。这些数据表明，SSP患者存在服药过量的高风险，其中一些可能是由于芬太尼暴露所致。应对日益严重的芬太尼疫情需要采取全面和创新的战略，处理药物使用模式和无家可归等结构性因素。
The opioid crisis remains a major public health issue in the US and beyond. Despite rapid rises in fentanyl-related mortality nationally, little is known about the role of fentanyl in the occurrence of non-fatal overdose among people who use drugs. We examined the prevalence of non-fatal overdose and perceived fentanyl exposure among syringe services program (SSP) clients and modeled the correlates of non-fatal overdose. Data were drawn from a cross-sectional survey of 203 SSP clients in Baltimore, MD recruited in 2016. Logistic regression models were used to identify the correlates of experiencing non-fatal overdose in the past 12 months. The majority (65%) was male, 52% were black, 41% were white, and 37% were homeless. Almost all (97%) used heroin, 64% injected heroin with cocaine (i.e., speedball), and many used other types of drugs. Half (53%) perceived fentanyl presence in their drugs either half, most or all of the time. Lifetime and past 12 month prevalence of non-fatal overdose were 58 and 31%, respectively. Independent correlates of non-fatal overdose in the past 12 months were perceiving fentanyl in drugs more than half the time (aOR = 2.79; 95% CI = 1.00–4.68), speedball injection (aOR = 2.80, 95% CI = 1.26–6.23), non-prescription buprenorphine use (aOR = 6.37; 95% CI = 2.86–14.17), and homelessness (aOR = 3.07; 95% CI = 1.28–7.39). These data demonstrate that SSP clients are at high-risk of overdose, some of which is likely attributable to fentanyl exposure. Addressing the rising fentanyl epidemic will require comprehensive and innovative strategies that attend to drug use patterns and structural factors such as homelessness.
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影响因子：
4.4
作者：
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通讯作者：
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影响因子：
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通讯作者：
Tardiff, K
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4.2
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通讯作者：
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