Gender-Specific Interactions in a Visual Object Recognition Task in Persons with Opioid Use Disorder.
Gender-Specific Interactions in a Visual Object Recognition Task in Persons with Opioid Use Disorder.
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DOI：
10.3390/biomedicines11092460
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发表时间：
2023-09-05
期刊：
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
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过去二十年来，阿片类药物使用障碍（OUD）相关的过量死亡在全世界范围内已达到流行病的比例，据报告，男性的死亡率是女性的两倍。为了更好地理解OUD的认知神经科学，我们使用对照、横断面、年龄匹配（18-56岁）的设计，在一个简单的视觉物体识别Go/No-Go任务中，评估了OUD与年龄和性别匹配的非OUD对照组的男性和女性参与者的脑电图（EEG）反应。总的来说，女性的反应时间（RT）明显比男性慢。此外，非OUD对照组的EEG N200和P300事件相关电位（ERP）振幅男性显著较大，而其潜伏期显著短于女性。然而，虽然N200和P300的振幅没有显着影响OUD的男性或女性在这项任务中，lavonis也受到影响的差异，男性与女性OUD。因此，对于N200和P300，男性OUD参与者表现出较长的lavelet，而女性OUD参与者表现出较短的比非OUD对照。此外，在与任务中的性能相关的反馈消息期间，在所有参与者中发现了鲁棒振荡。尽管总体而言，男性在反馈信息中的α和β功率显着高于女性，但在所有患有OUD的参与者中，α和β振荡都表现出显着较低的功率。两者合计，这些研究结果表明，重要的性别OUD的认知处理和反映在这个简单的视觉任务的性能差异。
Opioid use disorder (OUD)-associated overdose deaths have reached epidemic proportions worldwide over the past two decades, with death rates for men reported at twice the rate for women. Using a controlled, cross-sectional, age-matched (18–56 y) design to better understand the cognitive neuroscience of OUD, we evaluated the electroencephalographic (EEG) responses of male and female participants with OUD vs. age- and gender-matched non-OUD controls during a simple visual object recognition Go/No-Go task. Overall, women had significantly slower reaction times (RTs) than men. In addition, EEG N200 and P300 event-related potential (ERP) amplitudes for non-OUD controls were significantly larger for men, while their latencies were significantly shorter than for women. However, while N200 and P300 amplitudes were not significantly affected by OUD for either men or women in this task, latencies were also affected differentially in men vs. women with OUD. Accordingly, for both N200 and P300, male OUD participants exhibited longer latencies while female OUD participants exhibited shorter ones than in non-OUD controls. Additionally, robust oscillations were found in all participants during a feedback message associated with performance in the task. Although alpha and beta power during the feedback message were significantly greater for men than women overall, both alpha and beta oscillations exhibited significantly lower power in all participants with OUD. Taken together, these findings suggest important gender by OUD differences in cognitive processing and reflection of performance in this simple visual task.
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影响因子：
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作者：
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影响因子：
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通讯作者：
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