Intravascular molecular-structural imaging with a miniaturized integrated near-infrared fluorescence and ultrasound catheter.
Intravascular molecular-structural imaging with a miniaturized integrated near-infrared fluorescence and ultrasound catheter.
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DOI：
10.1002/jbio.202100048
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发表时间：
2021-10
影响因子：
2.8
通讯作者：
Jaffer FA
中科院分区：
文献类型：
--
作者：
Kellnberger S;Wissmeyer G;Albaghdadi M;Piao Z;Li W;Mauskapf A;Rauschendorfer P;Tearney GJ;Ntziachristos V;Jaffer FA
冠状动脉疾病（CAD）仍然是导致死亡的主要原因，需要新的成像方法来更好地指导临床护理。我们报告了一种小型化的混合血管内导管和成像系统，用于在体冠状动脉全面成像。我们的导管总直径为1.0 mm（3.0 French），与独立的临床血管内超声（IVUS）导管相当，但可同时进行近红外荧光（NIRF）和IVUS分子结构成像。我们使用NIR荧光团在体外冠状动脉支架中演示了NIRF-IVUS成像，并比较了棱镜和球透镜传感器设计在低散射和高散射介质中的NIRF信号强度。接下来，猪冠状动脉的体内血管内成像显示了IVUS和距离校正NIRF图像上实验性CAD炎症的同步共配准分子结构成像。所获得的结果表明，NIRF-IVUS导管在推进独立IVUS方面具有实质性潜力，并能够对血管疾病进行全面的表型分析，以更好地评估和治疗CAD患者。猪动脉粥样硬化模型中左前降支冠状动脉的混合NIRF-IVUS体内成像横截面，共记录斑块炎症和结构信息。NIRF信息被编码在外部圆形色图中，并与描绘灰度超声的结构信息融合。比例尺，1 mm。
Coronary artery disease (CAD) remains a leading cause of mortality and warrants new imaging approaches to better guide clinical care. We report on a miniaturized, hybrid intravascular catheter and imaging system for comprehensive coronary artery imaging in vivo. Our catheter exhibits a total diameter of 1.0 mm (3.0 French), equivalent to standalone clinical intravascular ultrasound (IVUS) catheters but enables simultaneous near-infrared fluorescence (NIRF) and IVUS molecular-structural imaging. We demonstrate NIRF-IVUS imaging in vitro in coronary stents using NIR fluorophores, and compare NIRF signal strengths for prism and ball lens sensor designs in both low and high scattering media. Next, in vivo intravascular imaging in pig coronary arteries demonstrates simultaneous, co-registered molecular-structural imaging of experimental CAD inflammation on IVUS and distance-corrected NIRF images. The obtained results suggest substantiual potenital for the NIRF-IVUS catheter to advance standalone IVUS, and enable comprehensive phenotyping of vascular disease to better assess and treat patients with CAD. Hybrid NIRF-IVUS in vivo imaging cross-section of the left anterior descending coronary artery in a swine atherosclerosis model with co-registered plaque inflammation and structural information. NIRF information is encoded in the outer circular colormap and fused with structural information depicting greyscale ultrasound. Scale bar, 1 mm.
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影响因子：
14
作者：
Verjans, Johan W.;Osborn, Eric A.;Ughi, Giovanni J.;Press, Marcella A. Calfon;Hamidi, Ehsan;Antoniadis, Antonios P.;Papafaklis, Michail I.;Conrad, Mark F.;Libby, Peter;Stone, Peter H.;Cambria, Richard P.;Tearney, Guillermo J.;Jaffer, Farouc A.
通讯作者：
Jaffer, Farouc A.
影响因子：
4.6
作者：
Bec, Julien;Phipps, Jennifer E.;Marcu, Laura
通讯作者：
Marcu, Laura
影响因子：
3.5
作者：
Marcu, Laura
通讯作者：
Marcu, Laura
DOI：
10.1016/j.jcmg.2015.11.020
发表时间：
2016-11
期刊：
JACC. Cardiovascular imaging
影响因子：
--
作者：
Ughi GJ;Wang H;Gerbaud E;Gardecki JA;Fard AM;Hamidi E;Vacas-Jacques P;Rosenberg M;Jaffer FA;Tearney GJ
通讯作者：
Tearney GJ
影响因子：
4.6
作者：
Lee MC;Park JC;Yoon DS;Han J;Kang S;Kamizono S;Om AS;Shin KH;Hagiwara A;Lee JS
通讯作者：
Lee JS