Weak associations between depressive symptom severity, depressive symptom clusters, and cognitive performance in young to middle-aged men without clinical depression.
Weak associations between depressive symptom severity, depressive symptom clusters, and cognitive performance in young to middle-aged men without clinical depression.
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DOI：
10.1080/13825585.2020.1840505
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发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
Vanderploeg RD
中科院分区：
文献类型：
--
作者：
Szymkowicz SM;Dotson VM;Vanderploeg RD
抑郁症是一种异质性疾病，具有不同的情感、认知和躯体症状组合。有证据表明，抑郁症状和不同的症状群与认知功能的特定方面有关，特别是在老年人。目前的研究旨在通过检查青年到中年人的抑郁症状严重性、症状群和认知功能来扩展现有文献。2560名男性样本(平均年龄=38.12±2.41岁)来自一项关于越南退伍军人的研究。参与者有有效的明尼苏达多相人格问卷(MMPI)和完整的认知测量。Bootstrap线性回归模型研究了认知表现与(I)MMPI抑郁量表(D)评分和(Ii)Harris-Lingo抑郁症状子量表评分在协变量调整后的关系。还进行了将样本分为非抑郁症状组和抑郁症状组的随访分析。在校正多次比较后，我们在整个样本中没有发现总体抑郁症状和认知之间的显著关系，但确实发现特定分量表(即主观抑郁和精神迟钝)与注意力控制措施之间存在负相关。在小组分析中，在Bonferroni矫正后，总体抑郁症状、症状群和认知功能之间没有显著关系。研究结果表明，在没有临床抑郁症的年轻到中年男性中，抑郁症状严重程度、抑郁症状群和认知功能之间存在微弱的相关性，这进一步证明了在临床和非临床样本中，抑郁症状-认知关系的研究结果不一致。
Depression is a heterogeneous disorder with different affective, cognitive, and somatic symptom combinations. Evidence suggests that depressive symptoms and different symptom clusters are related to specific aspects of cognitive function, especially in older adults. The current study aimed to extend existing literature by examining depressive symptom severity, symptom clusters, and cognitive functioning in young-to-middle aged adults. A sample of 2,560 men (mean age = 38.12 ± 2.41 years) was drawn from a study on Vietnam veterans. Participants had a valid Minnesota Multiphasic Personality Inventory (MMPI) and completed cognitive measures. Bootstrapped linear regression models investigated relationships between cognitive performance and (i) MMPI Depression (D) scale scores and (ii) Harris-Lingoes depression symptom subscale scores after covariate adjustments. Follow-up analyses separating the sample into non-elevated and elevated depressive symptoms groups were also conducted. After correcting for multiple comparisons, we found no significant relationships between total depressive symptoms and cognition for the entire sample, but did find inverse relationships between specific subscales (i.e., Subjective Depression and Mental Dullness) with a measure of attentional control. In the group analyses, there were no significant relationships between total depressive symptoms, symptom clusters, and cognitive functioning after Bonferroni correction. Findings suggest there are weak associations between depressive symptom severity, depressive symptom clusters, and cognitive functioning in young to middle-aged men without clinical depression, which adds to a body of literature showing inconsistent findings in depressive symptom – cognition relationships in both clinical and non-clinical samples.
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