Rat offspring's microbiota composition is predominantly shaped by the postnatal maternal diet rather than prenatal diet.

Rat offspring's microbiota composition is predominantly shaped by the postnatal maternal diet rather than prenatal diet.
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DOI:
10.1016/j.physbeh.2022.113987
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发表时间:
2023-01-01
影响因子:
2.9
通讯作者:
de La Serre, Claire B.
de La Serre, Claire B.
中科院分区:
医学3区
文献类型:
--
作者:
Schade, Ruth;Song, Lin;Cordner, Zachary A.;Ding, Hua;Peterson, Daniel A.;Moran, Timothy H.;Tamashiro, Kellie L.;de La Serre, Claire B.

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这项研究评估了母亲在怀孕期间与哺乳期间的饮食对后代肠道微生物群的影响。Sprague-Dawley母鼠在妊娠期间饲喂高脂肪(HF)或普通饲料,其雄性后代由食用相同或相反饲料(Chow-Chow、Chow-HF、HF-Chow和HF-HF)的不同母鼠饲养。微生物群分析表明,母亲哺乳期饮食,而不是怀孕饮食,决定了后代的微生物群在断奶。Turicibacter、Staphylococcus和Ruminococcus的丰度增加是饲料哺乳组的特征。乳球菌、链球菌和副拟杆菌是HF泌乳组的特征,与后代体重呈正相关。
This study assessed the impact of maternal diet during pregnancy versus lactation on offspring gut microbiota. Sprague-Dawley dams were fed high fat (HF) or Chow diets during pregnancy, and their male offspring were raised by a different dam consuming the same or opposite diet (Chow-Chow, Chow-HF, HF-Chow, and HF-HF). Microbiota analysis showed that maternal lactation diet, rather than pregnancy diet, determined offspring microbiota profiles at weaning. Increased abundances of Turicibacter, Staphylococcus, and Ruminococcus were characteristic of chow lactation groups. Lactococcus, Streptococcus, and Parabacteroides were characteristic of HF lactation groups and positively correlated with offspring body weight.
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影响因子: 4.5
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