Altered intrinsic local activity and cognitive dysfunction in HIV patients: A resting-state fMRI study.
Altered intrinsic local activity and cognitive dysfunction in HIV patients: A resting-state fMRI study.
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DOI：
10.1371/journal.pone.0207146
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Shin NY
中科院分区：
文献类型：
--
作者：
Bak Y;Jun S;Choi JY;Lee Y;Lee SK;Han S;Shin NY
描述HIV患者静息态脑激活模式并研究认知功能下降的改变区域。12名男性HIV患者与完整的认知（HIV-IC），10名与HIV相关的神经认知障碍（HAND），和11名男性健康对照（HC）进行静息态功能MRI（rsfMRI）。计算三个rsfMRI值，区域均匀性（ReHo），低频波动幅度（ALFF）和分数ALFF（fALFF），并在组间进行比较。rsfMRI值与神经心理测验进行相关分析。rsfMRI分析显示，与HC相比，HIV-IC和HAND的额叶区域的rsfMRI值降低，而后脑区域的rsfMRI值增加。当直接与HIV-IC相比时，HAND在眶额皮质中表现出较低的fALFF，而在初级感觉运动区中表现出较高的ReHo。此外，减少眶额fALFF，增加感觉运动ReHo，以及两个值之间的较大差异与HIV患者的言语记忆和执行功能下降高度相关。无论认知状态如何，在HIV患者中发现了局部内在活动的改变。眶额皮质和初级感觉运动区在HAND中相对于HIV-IC更受干扰，并且与行为表现相关，这表明这些区域与HIV患者的认知障碍相关。
To characterize resting-state brain activation patterns and investigate altered areas for cognitive decline in HIV patients. Twelve male HIV patients with intact cognition (HIV-IC), 10 with HIV-associated neurocognitive disorder (HAND), and 11 male healthy controls (HC) underwent resting-state functional MRI (rsfMRI). Three rsfMRI values, regional homogeneity (ReHo), amplitude of low-frequency fluctuation (ALFF), and fractional ALFF (fALFF) were calculated and compared between groups. Correlation analyses were performed between rsfMRI values and neuropsychological tests. rsfMRI analyses revealed decreased rsfMRI values in the frontal areas, and increases in the posterior brain regions for both HIV-IC and HAND compared to HC. When directly compared to HIV-IC, HAND showed lower fALFF in the orbitofrontal cortex and higher ReHo in the primary sensorimotor area. Additionally, decreased orbitofrontal fALFF, increased sensorimotor ReHo, and a larger difference between the two values were highly correlated with decreased verbal memory and executive function in HIV patients. Regardless of cognitive status, altered local intrinsic activities were found in HIV patients. The orbitofrontal cortex and primary sensorimotor area were more disrupted in HAND relative to HIV-IC and correlated with behavioral performance, suggesting these areas are relevant to cognitive impairment in HIV patients.
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影响因子：
3.2
作者：
Becker KM;Heinrichs-Graham E;Fox HS;Robertson KR;Sandkovsky U;O'Neill J;Swindells S;Wilson TW
通讯作者：
Wilson TW
影响因子：
3
作者：
Ku NS;Lee Y;Ahn JY;Song JE;Kim MH;Kim SB;Jeong SJ;Hong KW;Kim E;Han SH;Song JY;Cheong HJ;Song YG;Kim WJ;Kim JM;Smith DM;Choi JY
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Choi JY
影响因子：
5.3
作者：
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通讯作者：
LJUNGBERG, T
影响因子：
3.2
作者：
Heaton, Robert K.;Franklin, Donald R.;Ellis, Ronald J.;McCutchan, J. Allen;Letendre, Scott L.;LeBlanc, Shannon;Corkran, Stephanie H.;Duarte, Nichole A.;Clifford, David B.;Woods, Steven P.;Collier, Ann C.;Marra, Christina M.;Morgello, Susan;Mindt, Monica Rivera;Taylor, Michael J.;Marcotte, Thomas D.;Atkinson, J. Hampton;Wolfson, Tanya;Gelman, Benjamin B.;McArthur, Justin C.;Simpson, David M.;Abramson, Ian;Gamst, Anthony;Fennema-Notestine, Christine;Jernigan, Terry L.;Wong, Joseph;Grant, Igor
通讯作者：
Grant, Igor
影响因子：
3.7
作者：
Ann HW;Jun S;Shin NY;Han S;Ahn JY;Ahn MY;Jeon YD;Jung IY;Kim MH;Jeong WY;Ku NS;Kim JM;Smith DM;Choi JY
通讯作者：
Choi JY