Reduced amygdala-orbitofrontal connectivity during moral judgments in youths with disruptive behavior disorders and psychopathic traits.
Reduced amygdala-orbitofrontal connectivity during moral judgments in youths with disruptive behavior disorders and psychopathic traits.
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DOI：
10.1016/j.pscychresns.2011.07.008
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发表时间：
2011-12-30
影响因子：
2.3
通讯作者：
Blair, R. J. R.
中科院分区：
文献类型：
--
作者：
Marsh, Abigail A.;Finger, Elizabeth C.;Fowler, Katherine A.;Jurkowitz, Ilana T. N.;Schechter, Julia C.;Yu, Henry H.;Pine, Daniel S.;Blair, R. J. R.
我们使用功能磁共振成像（fMRI）来研究具有破坏性行为障碍和精神病特征的青少年在道德判断任务中杏仁核和眶额皮质的功能障碍。使用功能磁共振成像对 14 名具有精神病特征的青少年和 14 名健康对照进行评估，同时他们在道德判断隐性关联任务中对非法和合法行为进行分类。然后使用方差和功能连接的随机效应分析来分析功能磁共振成像数据。具有精神病特征的青少年在对法律行动做出判断时表现出杏仁核活动减少，并且在执行任务时杏仁核和眶额皮质之间的功能连接减少。这些结果表明精神病特征与杏仁核和眶额皮质功能障碍有关。这种功能障碍可能与之前发现的该人群道德判断紊乱有关。
We used functional magnetic resonance imaging (fMRI) to investigate dysfunction in the amygdala and orbitofrontal cortex in adolescents with disruptive behavior disorders and psychopathic traits during a moral judgment task. Fourteen adolescents with psychopathic traits and 14 healthy controls were assessed using fMRI while they categorized illegal and legal behaviors in a moral judgment implicit association task. fMRI data were then analyzed using random-effects analysis of variance and functional connectivity. Youths with psychopathic traits showed reduced amygdala activity when making judgments about legal actions and reduced functional connectivity between the amygdala and orbitofrontal cortex during task performance. These results suggest that psychopathic traits are associated with amygdala and orbitofrontal cortex dysfunction. This dysfunction may relate to previous findings of disrupted moral judgment in this population.
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影响因子：
3.6
作者：
Blair, RJR;Colledge, E;Mitchell, DGV
通讯作者：
Mitchell, DGV
影响因子：
4.3
作者：
Blair, RJR;Monson, J;Frederickson, N
通讯作者：
Frederickson, N
影响因子：
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作者：
Blair, RJR;Mitchell, DGV;Newman, C
通讯作者：
Newman, C
影响因子：
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作者：
Finger, Elizabeth C.;Marsh, Abigail A.;Blair, James R.
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影响因子：
10.6
作者：
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通讯作者：
End, A