Stressful events induce long-term gut microbiota dysbiosis and associated post-traumatic stress symptoms in healthcare workers fighting against COVID-19.
Stressful events induce long-term gut microbiota dysbiosis and associated post-traumatic stress symptoms in healthcare workers fighting against COVID-19.
复制标题
压力事件会导致抗击 COVID-19 的医护人员出现长期肠道菌群失调以及相关的创伤后压力症状
DOI：
10.1016/j.jad.2022.02.024
复制
发表时间：
2022-04-15
影响因子：
6.6
通讯作者：
Ma X
中科院分区：
文献类型：
--
作者：
Gao F;Guo R;Ma Q;Li Y;Wang W;Fan Y;Ju Y;Zhao B;Gao Y;Qian L;Yang Z;He X;Jin X;Liu Y;Peng Y;Chen C;Chen Y;Gao C;Zhu F;Ma X
微生物群-肠-脑轴是被长时间的应激源干扰以产生大脑和行为障碍的关键途径。对抗COVID-19的一线医护人员（FHW）通常会经历压力事件序列并表现出一些精神症状;然而，肠道微生物群在这种压力诱导的精神问题中的作用仍不清楚。我们调查了FHW的心理压力与肠道微生物群之间的关系。我们使用全长16 S rRNA基因测序来表征肠道微生物群的纵向变化，并研究了微生物变化对FHWs精神状态的影响。应激事件在FHWs中引起显著的抑郁、焦虑和应激，并破坏肠道微生物组;肠道生态失调持续至少半年。在半年的随访期间，不同的微生物遵循离散的轨迹。与心理健康相关的微生物主要是粪杆菌属。和[Eubacterium] eligens group spp.具有抗炎作用。值得注意的是，预测模型表明，在第0天（两个月一线工作后立即），[霍氏真杆菌]组未培养细菌的低丰度和埃氏拟杆菌的高丰度是FHW中创伤后应激症状再现的重要决定因素。由于缺乏代谢组学证据和动物实验，导致肠道生态失调相关应激症状的发生机制尚不清楚。对抗COVID-19的应激事件序列诱导肠道微生物群的特征性纵向变化，这是动态精神状态变化的基础。
The microbiota-gut-brain axis is a key pathway perturbed by prolonged stressors to produce brain and behavioral disorders. Frontline healthcare workers (FHWs) fighting against COVID-19 typically experience stressful event sequences and manifest some mental symptoms; however, the role of gut microbiota in such stress-induced mental problems remains unclear. We investigated the association between the psychological stress of FHW and gut microbiota. We used full-length 16S rRNA gene sequencing to characterize the longitudinal changes in gut microbiota and investigated the impact of microbial changes on FHWs' mental status. Stressful events induced significant depression, anxiety, and stress in FHWs and disrupted the gut microbiome; gut dysbiosis persisted for at least half a year. Different microbes followed discrete trajectories during the half-year of follow-up. Microbes associated with mental health were mainly Faecalibacterium spp. and [Eubacterium] eligens group spp. with anti-inflammatory effects. Of note, the prediction model indicated that low abundance of [Eubacterium] hallii group uncultured bacterium and high abundance of Bacteroides eggerthii at Day 0 (immediately after the two-month frontline work) were significant determinants of the reappearance of post-traumatic stress symptoms in FHWs. The lack of metabolomic evidence and animal experiments result in the unclear mechanism of gut dysbiosis-related stress symptoms. The stressful event sequences of fighting against COVID-19 induce characteristic longitudinal changes in gut microbiota, which underlies dynamic mental state changes.
登录
查看更多内容
影响因子：
4.3
作者：
Joseph, Tyler A.;Shenhav, Liat;Peer, Itsik
通讯作者：
Peer, Itsik
影响因子：
5.8
作者：
Edgar, Robert C.
通讯作者：
Edgar, Robert C.
影响因子：
3.2
作者：
Huang, Yichen;Shi, Xing;Liang, Ying
通讯作者：
Liang, Ying
影响因子：
3
作者：
Li N;Wang Q;Wang Y;Sun A;Lin Y;Jin Y;Li X
通讯作者：
Li X
影响因子：
3.7
作者：
Bangsgaard Bendtsen KM;Krych L;Sørensen DB;Pang W;Nielsen DS;Josefsen K;Hansen LH;Sørensen SJ;Hansen AK
通讯作者：
Hansen AK