Vitamin D status during pregnancy and aspects of offspring health.

Vitamin D status during pregnancy and aspects of offspring health.
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DOI:
10.3390/nu2030389
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发表时间:
2010-03
期刊:
影响因子:
5.9
通讯作者:
Halliday J
Halliday J
中科院分区:
医学2区
文献类型:
--
作者:
Ponsonby AL;Lucas RM;Lewis S;Halliday J

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怀孕期间母亲维生素D水平低与后代的各种健康结果有关,从围产期影响到成人发病的疾病。母亲和婴儿脐带25(OH)D水平高度相关。在这里,我们回顾了这些不良健康影响的现有证据。大多数证据来自观察性流行病学研究,但随机对照试验正在进行中。迄今为止的证据支持妇女在怀孕期间应监测和治疗维生素D缺乏症,但怀孕期间血清25(OH)D水平的最佳和上限尚不清楚。
Low maternal vitamin D levels during pregnancy have been linked to various health outcomes in the offspring, ranging from periconceptional effects to diseases of adult onset. Maternal and infant cord 25(OH)D levels are highly correlated. Here, we review the available evidence for these adverse health effects. Most of the evidence has arisen from observational epidemiological studies, but randomized controlled trials are now underway. The evidence to date supports that women should be monitored and treated for vitamin D deficiency during pregnancy but optimal and upper limit serum 25(OH)D levels during pregnancy are not known.
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