Functional connectivity in the dorsal network of the cervical spinal cord is correlated with diffusion tensor imaging indices in relapsing-remitting multiple sclerosis.
Functional connectivity in the dorsal network of the cervical spinal cord is correlated with diffusion tensor imaging indices in relapsing-remitting multiple sclerosis.
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DOI：
10.1016/j.nicl.2022.103127
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发表时间：
2022
影响因子：
4.2
通讯作者：
Smith, Seth A.
中科院分区：
文献类型：
--
作者：
Combes, Anna J. E.;O'Grady, Kristin P.;Rogers, Baxter P.;Schilling, Kurt G.;Lawless, Richard D.;Visagie, Mereze;Houston, Delaney;Prock, Logan;Malone, Shekinah;Satish, Sanjana;Witt, Atlee A.;McKnight, Colin D.;Bagnato, Francesca;Gore, John C.;Smith, Seth A.
关键词：
低残疾RRMS患者的颈髓静息状态功能连接完整。背侧网络的高连通性与DTI指标相关，表明灰和白色物质受损。连接性增加可能代表支持临床功能的代偿机制。局灶性病变可能影响复发缓解型多发性硬化（RRMS）患者颈脊髓腹侧和背侧网络的功能连接（FC）。静息状态FC可以使用3 T下的功能性MRI（fMRI）测量。本研究试图确定FC的改变是否可能与外观正常的组织的损伤程度有关。在一组26名RRMS参与者中，分别采用扩散张量成像（DTI）和静息状态fMRI评估颈髓的组织完整性和FC，这些参与者具有高颈部病变负荷、低残疾和最低程度的感觉运动功能受损，以及健康对照。与对照组相比，RRMS组正常外观的白色物质中观察到较低的各向异性分数（FA）和较高的径向扩散率（RD）。组间腹侧和背侧网络的平均FC相似。在背侧感觉网络中较高的FC与正常组织中的几种DTI病理标志物之间存在显著相关性。在正常表现的灰质中，背侧FC与轴向扩散率（AD）（r = 0.46，p = 0.020）和平均扩散率（MD）（r = 0.43，p = 0.032）呈正相关。在外观正常的白色物质中，背侧FC与FA呈负相关（r =-0.43，p = 0.028），与RD（r = 0.49，p = 0.012）、AD（r = 0.42，p = 0.037）和MD（r = 0.53，p = 0.006）正相关。这些结果表明，增加连接，而保持在正常范围内，可能代表一种补偿机制，在响应结构损伤，以支持保留的感觉功能在RRMS。
Cervical cord resting-state functional connectivity is intact in low disability RRMS patients. Higher connectivity in the dorsal network is linked with DTI indices indicating gray and white matter damage. Increased connectivity may represent a compensatory mechanism to support clinical function. Focal lesions may affect functional connectivity (FC) of the ventral and dorsal networks in the cervical spinal cord of people with relapsing-remitting multiple sclerosis (RRMS). Resting-state FC can be measured using functional MRI (fMRI) at 3T. This study sought to determine whether alterations in FC may be related to the degree of damage in the normal-appearing tissue. Tissue integrity and FC in the cervical spinal cord were assessed with diffusion tensor imaging (DTI) and resting-state fMRI, respectively, in a group of 26 RRMS participants with high cervical lesion load, low disability, and minimally impaired sensorimotor function, and healthy controls. Lower fractional anisotropy (FA) and higher radial diffusivity (RD) were observed in the normal-appearing white matter in the RRMS group relative to controls. Average FC in ventral and dorsal networks was similar between groups. Significant associations were found between higher FC in the dorsal sensory network and several DTI markers of pathology in the normal-appearing tissue. In the normal-appearing grey matter, dorsal FC was positively correlated with axial diffusivity (AD) (r = 0.46, p = 0.020) and mean diffusivity (MD) (r = 0.43, p = 0.032). In the normal-appearing white matter, dorsal FC was negatively correlated with FA (r = −0.43, p = 0.028) and positively correlated with RD (r = 0.49, p = 0.012), AD (r = 0.42, p = 0.037) and MD (r = 0.53, p = 0.006). These results suggest that increased connectivity, while remaining within the normal range, may represent a compensatory mechanism in response to structural damage in support of preserved sensory function in RRMS.
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影响因子：
5.7
作者：
Klawiter, Eric C.;Schmidt, Robert E.;Trinkaus, Kathryn;Liang, Hsiao-Fang;Budde, Matthew D.;Naismith, Robert T.;Song, Sheng-Kwei;Cross, Anne H.;Benzinger, Tammie L.
通讯作者：
Benzinger, Tammie L.
影响因子：
5.7
作者：
Agosta, Federica;Valsasina, Paola;Filippi, Massimo
通讯作者：
Filippi, Massimo
DOI：
10.1073/pnas.1110024108
发表时间：
2011-11-22
影响因子：
11.1
作者：
Hawellek, David J.;Hipp, Joerg F.;Engel, Andreas K.
通讯作者：
Engel, Andreas K.
影响因子：
9.9
作者：
Naismith, Robert T.;Xu, Junqian;Cross, Anne H.
通讯作者：
Cross, Anne H.
影响因子：
11.2
作者：
Moll, Natalia M.;Rietsch, Anna M.;Thomas, Smitha;Ransohoff, Amy J.;Lee, Jar-Chi;Fox, Robert;Chang, Ansi;Ransohoff, Richard M.;Fisher, Elizabeth
通讯作者：
Fisher, Elizabeth