CATH: expanding the horizons of structure-based functional annotations for genome sequences.
CATH: expanding the horizons of structure-based functional annotations for genome sequences.
复制标题
DOI：
10.1093/nar/gky1097
复制
发表时间：
2019-01-08
影响因子：
14.9
通讯作者：
Orengo CA
中科院分区：
文献类型：
--
作者：
Sillitoe I;Dawson N;Lewis TE;Das S;Lees JG;Ashford P;Tolulope A;Scholes HM;Senatorov I;Bujan A;Ceballos Rodriguez-Conde F;Dowling B;Thornton J;Orengo CA
本文提供了CATH蛋白质结构分类数据库（http：//www.example.com）内的最新数据和发展的更新。www.cathdb.info该资源提供两个级别的发布：CATH-B，最新结构域边界和超家族分配的每日快照，以及CATH+，它添加了衍生数据层，如预测序列结构域，功能注释和功能聚类（称为功能家族或FunFams）。最新的CATH+版本（版本4.2）在结构数据的覆盖范围方面提供了巨大的更新。该版本将完全分类的结构域的数量增加了40%以上（从308999个结构域增加到434857个结构域），对应于组织成6119个超家族的序列数据的几乎两倍增加（从5300万个预测结构域增加到9500万个预测结构域）。包含至少一个指定CATH结构域的高分辨率蛋白质PDB链的覆盖率现在为90.2%（从上一版本的82.3%增加）。我们的网页中还实现了一些高度要求的功能：允许用户查看其查询序列与代表性FunFam结构之间的对齐，并提供工具，使其更容易查看域和链的完整结构上下文（多域架构）。
This article provides an update of the latest data and developments within the CATH protein structure classification database (http://www.cathdb.info). The resource provides two levels of release: CATH-B, a daily snapshot of the latest structural domain boundaries and superfamily assignments, and CATH+, which adds layers of derived data, such as predicted sequence domains, functional annotations and functional clustering (known as Functional Families or FunFams). The most recent CATH+ release (version 4.2) provides a huge update in the coverage of structural data. This release increases the number of fully- classified domains by over 40% (from 308 999 to 434 857 structural domains), corresponding to an almost two- fold increase in sequence data (from 53 million to over 95 million predicted domains) organised into 6119 superfamilies. The coverage of high-resolution, protein PDB chains that contain at least one assigned CATH domain is now 90.2% (increased from 82.3% in the previous release). A number of highly requested features have also been implemented in our web pages: allowing the user to view an alignment between their query sequence and a representative FunFam structure and providing tools that make it easier to view the full structural context (multi-domain architecture) of domains and chains.
登录
查看更多内容
影响因子：
14.9
作者：
Brandt BW;Heringa J
通讯作者：
Heringa J
影响因子：
14.9
作者：
Sillitoe I;Cuff AL;Dessailly BH;Dawson NL;Furnham N;Lee D;Lees JG;Lewis TE;Studer RA;Rentzsch R;Yeats C;Thornton JM;Orengo CA
通讯作者：
Orengo CA
DOI：
10.1007/978-1-4939-6622-6_7
发表时间：
2017-01-01
期刊：
BIOINFORMATICS, VOL I: DATA, SEQUENCE ANALYSIS, AND EVOLUTION, 2ND EDITION
影响因子：
--
作者：
Dawson, Natalie;Sillitoe, Ian;Orengo, Christine A.
通讯作者：
Orengo, Christine A.
影响因子：
12.3
作者：
Jiang Y;Oron TR;Clark WT;Bankapur AR;D'Andrea D;Lepore R;Funk CS;Kahanda I;Verspoor KM;Ben-Hur A;Koo da CE;Penfold-Brown D;Shasha D;Youngs N;Bonneau R;Lin A;Sahraeian SM;Martelli PL;Profiti G;Casadio R;Cao R;Zhong Z;Cheng J;Altenhoff A;Skunca N;Dessimoz C;Dogan T;Hakala K;Kaewphan S;Mehryary F;Salakoski T;Ginter F;Fang H;Smithers B;Oates M;Gough J;Törönen P;Koskinen P;Holm L;Chen CT;Hsu WL;Bryson K;Cozzetto D;Minneci F;Jones DT;Chapman S;Bkc D;Khan IK;Kihara D;Ofer D;Rappoport N;Stern A;Cibrian-Uhalte E;Denny P;Foulger RE;Hieta R;Legge D;Lovering RC;Magrane M;Melidoni AN;Mutowo-Meullenet P;Pichler K;Shypitsyna A;Li B;Zakeri P;ElShal S;Tranchevent LC;Das S;Dawson NL;Lee D;Lees JG;Sillitoe I;Bhat P;Nepusz T;Romero AE;Sasidharan R;Yang H;Paccanaro A;Gillis J;Sedeño-Cortés AE;Pavlidis P;Feng S;Cejuela JM;Goldberg T;Hamp T;Richter L;Salamov A;Gabaldon T;Marcet-Houben M;Supek F;Gong Q;Ning W;Zhou Y;Tian W;Falda M;Fontana P;Lavezzo E;Toppo S;Ferrari C;Giollo M;Piovesan D;Tosatto SC;Del Pozo A;Fernández JM;Maietta P;Valencia A;Tress ML;Benso A;Di Carlo S;Politano G;Savino A;Rehman HU;Re M;Mesiti M;Valentini G;Bargsten JW;van Dijk AD;Gemovic B;Glisic S;Perovic V;Veljkovic V;Veljkovic N;Almeida-E-Silva DC;Vencio RZ;Sharan M;Vogel J;Kansakar L;Zhang S;Vucetic S;Wang Z;Sternberg MJ;Wass MN;Huntley RP;Martin MJ;O'Donovan C;Robinson PN;Moreau Y;Tramontano A;Babbitt PC;Brenner SE;Linial M;Orengo CA;Rost B;Greene CS;Mooney SD;Friedberg I;Radivojac P
通讯作者：
Radivojac P
影响因子：
14.9
作者：
Ribeiro, Antonio J. M.;Holliday, Gemma L.;Thornton, Janet M.
通讯作者：
Thornton, Janet M.