Role of Hippocampal CA2 Region in Triggering Sharp-Wave Ripples.
Role of Hippocampal CA2 Region in Triggering Sharp-Wave Ripples.
复制标题
DOI：
10.1016/j.neuron.2016.08.008
复制
发表时间：
2016-09-21
期刊：
影响因子：
16.2
通讯作者：
Berényi A
中科院分区：
文献类型：
--
作者：
Oliva A;Fernández-Ruiz A;Buzsáki G;Berényi A
Sharp-wave ripples (SPW-Rs) in the hippocampus are implied in memory consolidation, as shown by observational and interventional experiments. However, the mechanism of their generation remains unclear. Using two-dimensional silicon probe arrays, we investigated the propagation of SPW-Rs across the hippocampal CA1, CA2, and CA3 subregions. Synchronous activation of CA2 ensembles preceded SPW-R-related population activity in CA3 and CA1 regions. Deep CA2 neurons gradually increased their activity prior to ripples and were suppressed during the population bursts of CA3-CA1 neurons (ramping cells). Activity of superficial CA2 cells preceded the activity surge in CA3-CA1 (phasic cells). The trigger role of the CA2 region in SPW-R was more pronounced during waking than sleeping. These results point to the CA2 region as an initiation zone for SPW-Rs. Oliva et al. show that sharp-wave ripple (SPW-R) related activation of CA2 neurons precede those in CA3 and CA1. Deep CA2 cells gradually increase their activity prior to SPW-Rs, establishing the CA2 region as a potential trigger for SPW-R generation.
登录
查看更多内容
影响因子：
16.2
作者：
Chevaleyre V;Siegelbaum SA
通讯作者：
Siegelbaum SA
影响因子：
25
作者：
Girardeau, Gabrielle;Benchenane, Karim;Zugaro, Michael B.
通讯作者：
Zugaro, Michael B.
影响因子：
5.3
作者：
Fernandez-Ruiz, Antonio;Munoz, Sagrario;Herreras, Oscar
通讯作者：
Herreras, Oscar
社会和新颖的环境修改了海马CA2空间的表示。
影响因子：
16.6
作者：
Alexander GM;Farris S;Pirone JR;Zheng C;Colgin LL;Dudek SM
通讯作者：
Dudek SM
DOI：
10.1038/nrn.2015.22
发表时间：
2016-02
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Dudek SM;Alexander GM;Farris S
通讯作者：
Farris S