A new anabolic compound, LLP2A-Ale, reserves periodontal bone loss in mice through augmentation of bone formation.
A new anabolic compound, LLP2A-Ale, reserves periodontal bone loss in mice through augmentation of bone formation.
复制标题
DOI：
10.1186/s40360-020-00454-x
复制
发表时间：
2020-11-13
影响因子：
2.9
通讯作者：
Yao W
中科院分区：
文献类型：
--
作者：
Jiang M;Liu L;Liu R;Lam KS;Lane NE;Yao W
Currently, there are no effective medications to reverse periodontal disease (PD)-induced bone loss. The objective of this study was to test a new anabolic compound, LLP2A-Ale, or with the combination treatment of mesenchymal stromal cell (MSC), in the treatment of bone loss secondary to PD. PD was induced in mice by placing a ligature around the second right molar. At one week after disease induction, the mice were treated with placebo, LLP2A-Ale, MSCs, or combination of LLP2A-Ale + MSCs, and euthanized at week 4. We found that PD induced alveolar bone loss that was associated with reduced bone formation. LLP2A-Ale alone or in combination with MSCs sustained alveolar bone formation and reversed alveolar bone loss. Additionally, PD alone caused systemic inflammation and increased the circulating levels of G-CSF, IP-10, MIP-1a, and MIP2, which were suppressed by LLP2A-Ale +/− MSCs. LLP2A-Ale +/− MSCs increased bone formation at the peripheral skeletal site (distal femur), which was otherwise suppressed by PD. Our findings indicated that LLP2A-Ale treatment rescued alveolar bone loss caused by PD, primarily by increasing bone formation. LLP2A-Ale also attenuated the circulating levels of a series of inflammatory cytokines and reversed the PD-induced suppression of systemic bone formation.
登录
查看更多内容
DOI：
10.1590/1678-77572016-0149
发表时间：
2017-03
期刊：
Journal of applied oral science : revista FOB
影响因子：
--
作者：
Santos BF;Souza EQ;Brigagão MR;Lima DC;Fernandes LA
通讯作者：
Fernandes LA
DOI：
10.5114/aoms.2014.40738
发表时间：
2014-02-24
期刊：
Archives of medical science : AMS
影响因子：
--
作者：
Kos M
通讯作者：
Kos M
影响因子：
2.8
作者：
BEAUPRE, GS;ORR, TE;CARTER, DR
通讯作者：
CARTER, DR
影响因子：
2.2
作者：
Abe, Toshiharu;Hajishengallis, George
通讯作者：
Hajishengallis, George
影响因子：
7
作者：
Kim, G. -W.;Han, M. -S.;Beier, F.
通讯作者：
Beier, F.