Molecular cloning and characterization of the translationally controlled tumor protein from Fenneropenaeus chinensis
Molecular cloning and characterization of the translationally controlled tumor protein from Fenneropenaeus chinensis
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DOI：
10.1007/s11033-008-9369-2
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发表时间：
2009-09
影响因子：
2.8
通讯作者：
Wang, Jin-Xing
中科院分区：
文献类型：
--
作者：
Wang, Shuai;Zhao, Xiao-Fan;Wang, Jin-Xing
恶性肿瘤控制蛋白（TCTP）是一种多功能蛋白，在各种复杂的生命过程中发挥着重要作用。本研究从中国明对虾（Fenneropenaeus chinensis）中克隆了一个新的TCTP cDNA，命名为Fc-TCTP。该基因全长711 bp，开放阅读框为507 bp，编码168个氨基酸，包括一个TCTP结构域。此外，本研究分析了该基因的表达模式时，它响应感染特异性鳗弧菌和白色综合征病毒（WSSV）。基于结果，Fc-TCTP存在于所有分析的组织中。此外，Fc-TCTP的表达水平下降后，已被细菌感染，但上调肝胰腺后，已暴露于WSSV。同样，Fc-TCTP蛋白在其暴露于病毒期间上调。这些结果表明，Fc-TCTP可能参与了F. chinensis。
The translationally controlled tumor protein (TCTP) is a multi-functioning protein that performs vital roles, particularly in various complicated life processes. In this study, a new TCTP cDNA was cloned from Fenneropenaeus chinensis and hence was designated as Fc-TCTP. Its length is 711 bp, and it is characterized by 507-bp open reading frame that encodes a deduced 168-amino acid protein, including a TCTP domain. Moreover, this study analyzed the expression patterns of this gene when it responds to infection specifically with Vibrio anguillarum and the white spot syndrome virus (WSSV). Based on the results, Fc-TCTP was present in all the analyzed tissues. Additionally, Fc-TCTP's expression level decreased after having been infected by bacteria, but was upregulated in the hepatopancreas after having been exposed to WSSV. Likewise, the Fc-TCTP protein was upregulated during its exposure to the virus. These results suggest that Fc-TCTP could well be involved in the antiviral response in F. chinensis.
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影响因子：
4.4
作者：
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通讯作者：
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DOI：
10.1038/90415
发表时间：
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期刊：
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影响因子：
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作者：
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影响因子：
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