Cell membrane coated-nanoparticles for cancer immunotherapy.
Cell membrane coated-nanoparticles for cancer immunotherapy.
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DOI：
10.1016/j.apsb.2022.02.023
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发表时间：
2022-08
影响因子：
14.5
通讯作者：
Hu, Fuqiang
中科院分区：
文献类型：
--
作者：
Zeng, Yingping;Li, Sufen;Zhang, Shufen;Wang, Li;Yuan, Hong;Hu, Fuqiang
关键词：
肿瘤免疫治疗通过激活自身免疫系统，有效抑制肿瘤进展，具有低毒、高效的特点。部分肿瘤免疫疗法对临床肿瘤治疗有积极作用。然而，肿瘤免疫治疗仍然受到肿瘤异质性、免疫细胞失能、肿瘤免疫抑制微环境和全身免疫毒性的限制。细胞膜包被纳米颗粒（CMCNs）继承了丰富的源细胞相关功能，包括“自我”标记、与免疫系统的交叉对话、生物靶向和特定区域的归巢。这使它们具有更好的生物相容性、弱免疫原性、免疫逃逸、长循环和肿瘤靶向性等特性。因此，它们被应用于精确输送药物和促进癌症免疫治疗的效果。本文综述了用于肿瘤免疫治疗的仿生CMCNs的最新研究进展，概述了现有的特异性肿瘤免疫治疗方法，探讨了各种膜包被纳米粒子的独特功能和分子机制，并分析了CMCNs在临床转化中面临的挑战。细胞膜包被纳米颗粒继承了丰富的源细胞相关功能，具有独特的优势。本文就其在肿瘤免疫治疗中的应用作一综述，以期提供一些见解。
Cancer immunotherapy can effectively inhibit cancer progression by activating the autoimmune system, with low toxicity and high effectiveness. Some of cancer immunotherapy had positive effects on clinical cancer treatment. However, cancer immunotherapy is still restricted by cancer heterogeneity, immune cell disability, tumor immunosuppressive microenvironment and systemic immune toxicity. Cell membrane-coated nanoparticles (CMCNs) inherit abundant source cell-relevant functions, including “self” markers, cross-talking with the immune system, biological targeting, and homing to specific regions. These enable them to possess preferred characteristics, including better biological compatibility, weak immunogenicity, immune escaping, a prolonged circulation, and tumor targeting. Therefore, they are applied to precisely deliver drugs and promote the effect of cancer immunotherapy. In the review, we summarize the latest researches of biomimetic CMCNs for cancer immunotherapy, outline the existing specific cancer immune therapies, explore the unique functions and molecular mechanisms of various cell membrane-coated nanoparticles, and analyze the challenges which CMCNs face in clinical translation. Cell membrane-coated nanoparticles inherit abundant source cell-relevant functions, and have unique advantages. The review focuses on the recent researches of their applications in cancer immunotherapy to provide some insights.
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