A Tuneable, Photocurable, Poly(Caprolactone)-Based Resin for Tissue Engineering-Synthesis, Characterisation and Use in Stereolithography.
A Tuneable, Photocurable, Poly(Caprolactone)-Based Resin for Tissue Engineering-Synthesis, Characterisation and Use in Stereolithography.
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DOI：
10.3390/molecules26051199
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发表时间：
2021-02-24
期刊：
影响因子：
--
通讯作者：
Claeyssens F
中科院分区：
文献类型：
--
作者：
Field J;Haycock JW;Boissonade FM;Claeyssens F
光固化成型是一种用于生产组织工程支架的有用的增材制造技术。在这里，我们提出了一种可调的，易于制造，光固化树脂用于立体光刻，广泛使用的生物材料，聚（己内酯）（PCL）的基础上。将PCL三醇甲基丙烯酸化至不同程度，并与光引发剂混合以产生可光固化的预聚物树脂，其在UV光下固化以产生细胞相容性材料。这项研究表明，聚（己内酯）甲基丙烯酸酯（PCLMA）可以产生一系列的机械性能和降解速率。通过提高预聚体的甲基丙烯酸酯化度（DM），交联PCLMA的杨氏模量可在0.12- 3.51MPa之间变化。加速降解速率也从17天的完全降解降低到21天的非显著降解。通过使用微立体光刻生产各种不同的3D结构，证明了树脂的增材制造能力。在这里，β-胡萝卜素被用作一种新型的细胞相容性光吸收剂，并通过控制固化深度来实现复杂几何形状的生产。这里提出的PCLMA提供了一个有吸引力的，可调的生物材料，用于生产组织工程支架的广泛应用。
Stereolithography is a useful additive manufacturing technique for the production of scaffolds for tissue engineering. Here we present a tuneable, easy-to-manufacture, photocurable resin for use in stereolithography, based on the widely used biomaterial, poly(caprolactone) (PCL). PCL triol was methacrylated to varying degrees and mixed with photoinitiator to produce a photocurable prepolymer resin, which cured under UV light to produce a cytocompatible material. This study demonstrates that poly(caprolactone) methacrylate (PCLMA) can be produced with a range of mechanical properties and degradation rates. By increasing the degree of methacrylation (DM) of the prepolymer, the Young’s modulus of the crosslinked PCLMA could be varied from 0.12–3.51 MPa. The accelerated degradation rate was also reduced from complete degradation in 17 days to non-significant degradation in 21 days. The additive manufacturing capabilities of the resin were demonstrated by the production of a variety of different 3D structures using micro-stereolithography. Here, β-carotene was used as a novel, cytocompatible photoabsorber and enabled the production of complex geometries by giving control over cure depth. The PCLMA presented here offers an attractive, tuneable biomaterial for the production of tissue engineering scaffolds for a wide range of applications.
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影响因子：
2.2
作者：
Borschel, GH;Kia, KF;Dennis, RG
通讯作者：
Dennis, RG
影响因子：
14
作者：
Chew, Sing Ylan;Mi, Ruifa;Leong, Kam W.
通讯作者：
Leong, Kam W.
DOI：
10.1126/science.aav9750
发表时间：
2019-05-03
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Grigoryan B;Paulsen SJ;Corbett DC;Sazer DW;Fortin CL;Zaita AJ;Greenfield PT;Calafat NJ;Gounley JP;Ta AH;Johansson F;Randles A;Rosenkrantz JE;Louis-Rosenberg JD;Galie PA;Stevens KR;Miller JS
通讯作者：
Miller JS
影响因子：
2.1
作者：
Evangelista, Maristella S.;Perez, Mireya;Evans, Gregory R. D.
通讯作者：
Evans, Gregory R. D.
影响因子：
6.2
作者：
Green, Brian J.;Worthington, Kristan S.;Guymon, C. Allan
通讯作者：
Guymon, C. Allan