Functional and structural correlates of the aging brain: relating visual cortex (V1) gamma band responses to age-related structural change.
Functional and structural correlates of the aging brain: relating visual cortex (V1) gamma band responses to age-related structural change.
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衰老大脑的功能和结构相关性：将视觉皮层（V1）伽马条带对与年龄相关的结构变化的响应。
DOI：
10.1002/hbm.21339
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发表时间：
2012-09
影响因子：
4.8
通讯作者：
Muthukumaraswamy, Suresh D.
中科院分区：
文献类型：
--
作者：
Gaetz, William;Roberts, Timothy P. L.;Singh, Krish D.;Muthukumaraswamy, Suresh D.
伽马带反应被认为是哺乳动物大脑信息处理的关键神经特征，但人们对与年龄相关的成熟如何影响伽马带反应知之甚少。最近基于 MRI 的研究表明，大脑成熟伴随着灰质和白质的明显结构变化，但这些变化与大脑功能的对应关系尚不清楚。本研究的目的是将视觉皮层 (V1) 伽马带反应与年龄相关的结构变化联系起来。我们评估了 MEG 测量的伽玛带对对比光栅刺激和结构 MRI 的反应，这些反应来自两个独立研究中心（英国卡迪夫大学 CUBRIC 的 MEG 实验室和费城儿童医院卢里家庭基金会 MEG 成像中心 (CHOP)）观察的参与者。汇总的参与者数据 (N=59) 年龄范围为 8.7 岁至 45.3 岁。我们评估了年龄与 MEG 伽马带频率和振幅之间的线性关联，以及年龄与枕叶 MRI 体积参数之间的线性关联。我们的 MEG 研究结果显示，伽马能带频率与年龄呈显着负相关。枕叶的脑体积分析还显示，年龄与踝周和楔叶区域的皮质厚度之间存在显着的负相关性。我们的功能性 MEG 和结构 MRI 结果显示了由于成熟而产生的区域特定变化，因此可能为理解神经发育、成熟和与年龄相关的衰退的生理过程提供信息。此外，（据我们所知）这项研究是首次发表的跨 MEG 中心多中心数据共享的演示。
The gamma band response is thought to be a key neural signature of information processing in the mammalian brain, yet little is known about how age-related maturation influences the gamma-band response. Recent MRI based studies have shown that brain maturation is accompanied by clear structural changes in both grey and white matter, yet the correspondence of these changes to brain function is unclear. The objective of this study was to relate visual cortex (V1) gamma-band responses to age-related structural change. We evaluated MEG measured gamma-band responses to contrast gratings stimuli and structural MRIs from participants observed from 2 separate research centers (MEG lab at CUBRIC, Cardiff University, UK, and the Lurie Family Foundations MEG Imaging Center, (CHOP) at the Children’s Hospital of Philadelphia). Pooled participant data (N=59) ranged in age from 8.7 to 45.3 yrs. We assessed linear associations between age and MEG gamma-band frequency and amplitude, as well as between age and MRI volumetric parameters of the occipital lobe. Our MEG findings revealed a significant negative correlation for gamma band frequency vs. age. Volumetric brain analysis from the occipital lobe also revealed significant negative correlations between age and the cortical thickness of pericalcarine and cuneus areas. Our functional MEG and structural MRI findings shows regionally specific changes due to maturation and may thus be informative for understanding physiological processes of neural development, maturation, and age-related decline. In addition, this study represents (to our knowledge), the first published demonstration of multi-centre data sharing across MEG centers.
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影响因子：
5.7
作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
Dale, AM
影响因子：
--
作者：
Bartzokis, G;Beckson, M;Mintz, J
通讯作者：
Mintz, J
影响因子：
2.5
作者：
Gaetz, WC;Cheyne, DO
通讯作者：
Cheyne, DO
影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
通讯作者：
Sereno, MI
影响因子：
5.7
作者：
Fischl, B;Salat, DH;Dale, AM
通讯作者：
Dale, AM