Cognitive therapy versus medication for depression: treatment outcomes and neural mechanisms.

Cognitive therapy versus medication for depression: treatment outcomes and neural mechanisms.
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DOI:
10.1038/nrn2345
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发表时间:
2008-10
影响因子:
34.7
通讯作者:
Hollon, Steven D.
Hollon, Steven D.
中科院分区:
医学1区
文献类型:
--
作者:
DeRubeis, Robert J.;Siegle, Greg J.;Hollon, Steven D.

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抑郁症是最常见且最具致残性的精神障碍之一。研究表明,认知疗法在治疗抑郁症方面与抗抑郁药物一样有效,而且即使在停止治疗后,它似乎也能降低复发的风险。认知疗法和抗抑郁药物可能涉及一些相似的神经机制,以及各自特有的机制。有朝一日,对这些机制的精确描述可能会被用于指导治疗选择并改善治疗效果。
Depression is one of the most prevalent and debilitating of the psychiatric disorders. Studies have shown that cognitive therapy is as efficacious as antidepressant medications at treating depression, and it seems to reduce the risk of relapse even after its discontinuation. Cognitive therapy and antidepressant medication probably engage some similar neural mechanisms, as well as mechanisms that are distinctive to each. A precise specification of these mechanisms might one day be used to guide treatment selection and improve outcomes.
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