Synthesis and characterization of antibacterial dental monomers and composites.
Synthesis and characterization of antibacterial dental monomers and composites.
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DOI：
10.1002/jbm.b.32683
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发表时间：
2012-05
影响因子：
3.4
通讯作者：
Fan, Yuwei
中科院分区：
文献类型：
--
作者：
Xu, Xiaoming;Wang, Yapin;Liao, Sumei;Wen, Zezhang T.;Fan, Yuwei
本研究的目的是合成抗菌甲基丙烯酸酯和甲基丙烯酰胺单体，并制备抗菌释氟牙科复合材料。合成了三种含长链季铵盐氟化物、1，2-甲基丙烯酰胺-N，N，N-三甲基十二烷-1-氟化铵(单体I)、N-苄基-11-(甲基丙烯酰氧基)-N，N-二甲基十一烷-1-氟化铵(单体II)和甲基丙烯氧基十一烷基氟化铵(单体III)的甲基丙烯酸酯或甲基丙烯酰胺类抗菌单体。抗菌单体II对变形链球菌的细胞毒性试验和杀菌试验表明，抗菌单体II优于单体I和单体III。研制了一系列含0~6%抗菌单体II的牙科复合材料，并对其转化率、弯曲强度、吸水性、溶解性和对变形链球菌生物膜的抑制作用进行了测试。还研制了一种抗菌释氟牙科复合材料，并对其弯曲强度和氟化物释放量进行了测试。含3%单体II的牙科复合体对变形链球菌生物被膜的形成有明显的抑制作用，且对其物理机械性能无明显影响。所述新型抗菌单体可与含有三元氟化锆络合物的释氟单体一起使用，形成新型抗菌释氟牙科复合材料。这种新型牙科复合材料有望具有更高的防腐效果和更长的使用寿命。
The objective of this study is to synthesize antibacterial methacrylate and methacrylamide monomers and formulate antibacterial fluoride-releasing dental composites. Three antibacterial methacrylate or methacrylamide monomers containing long-chain quaternary ammonium fluoride, 1,2-methacrylamido-N,N,N-trimethyldodecan-1-aminium fluoride (monomer I), N-benzyl-11-(methacryloyloxy)-N,N-dimethylundecan-1-aminium fluoride (monomer II), and methacryloxyldecylpyridinium fluoride (monomer III) have been synthesized and analyzed by nuclear magnetic resonance (NMR) and mass spectrometry (MS). The cytotoxicity test and bactericidal test against Streptococcus mutans indicate that antibacterial monomer II is superior to monomers I and III. A series of dental composites containing 0–6% of antibacterial monomer II have been formulated and tested for degree of conversion (DC), flexure strength, water sorption, solubility, and inhibition of S. mutans biofilms. An antibacterial fluoride-releasing dental composite has also been formulated and tested for flexure strength and fluoride release. The dental composite containing 3% of monomer II has a significant effect against S. mutans biofilm formation without major adverse effects on its physical and mechanical properties. The new antibacterial monomers can be used together with the fluoride-releasing monomers containing a ternary zirconiun- fluoride chelate to formulate a new antibacterial fluoride- releasing dental composite. Such a new dental composite is expected to have higher anticaries efficacy and longer service life.
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影响因子：
7.6
作者：
ANDRES, CJ;SHAEFFER, JC;WINDELER, AS
通讯作者：
WINDELER, AS
DOI：
10.1002/jbm.820160207
发表时间：
1982-01-01
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
--
作者：
ADDY, M;THAW, M
通讯作者：
THAW, M
影响因子：
2.9
作者：
ADDY, M
通讯作者：
ADDY, M
影响因子：
7.6
作者：
Ling, L.;Xu, X.;Diwan, R. M.
通讯作者：
Diwan, R. M.
影响因子：
7.6
作者：
MALTZ, M;EMILSON, CG
通讯作者：
EMILSON, CG