Natural-cause mortality and long-term exposure to particle components: an analysis of 19 European cohorts within the multi-center ESCAPE project.
Natural-cause mortality and long-term exposure to particle components: an analysis of 19 European cohorts within the multi-center ESCAPE project.
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DOI：
10.1289/ehp.1408095
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发表时间：
2015-06
影响因子：
10.4
通讯作者：
Brunekreef B
中科院分区：
文献类型：
--
作者：
Beelen R;Hoek G;Raaschou-Nielsen O;Stafoggia M;Andersen ZJ;Weinmayr G;Hoffmann B;Wolf K;Samoli E;Fischer PH;Nieuwenhuijsen MJ;Xun WW;Katsouyanni K;Dimakopoulou K;Marcon A;Vartiainen E;Lanki T;Yli-Tuomi T;Oftedal B;Schwarze PE;Nafstad P;De Faire U;Pedersen NL;Östenson CG;Fratiglioni L;Penell J;Korek M;Pershagen G;Eriksen KT;Overvad K;Sørensen M;Eeftens M;Peeters PH;Meliefste K;Wang M;Bueno-de-Mesquita HB;Sugiri D;Krämer U;Heinrich J;de Hoogh K;Key T;Peters A;Hampel R;Concin H;Nagel G;Jaensch A;Ineichen A;Tsai MY;Schaffner E;Probst-Hensch NM;Schindler C;Ragettli MS;Vilier A;Clavel-Chapelon F;Declercq C;Ricceri F;Sacerdote C;Galassi C;Migliore E;Ranzi A;Cesaroni G;Badaloni C;Forastiere F;Katsoulis M;Trichopoulou A;Keuken M;Jedynska A;Kooter IM;Kukkonen J;Sokhi RS;Vineis P;Brunekreef B
研究表明，死亡率与长期暴露于颗粒物空气污染之间存在关联。很少有队列研究估计了颗粒物的元素组成对死亡率的影响。我们的目的是研究自然原因死亡率和长期暴露于颗粒物的元素成分之间的关系。使用了19项欧洲队列研究的死亡率和混杂因素数据。住宅暴露于八个优先选择的颗粒物（PM）的组成部分，其特征在于以下严格标准化的协议。利用土地利用回归模型估算了≤ 2.5 μm（PM2.5）和≤ 10 μm（PM10）颗粒物中铜、铁、钾、镍、硫、硅、钒和锌的年均浓度。使用考克斯比例风险模型对死亡率和空气污染之间的关联进行队列特定统计分析，使用通用协议，然后进行荟萃分析。总研究人群包括291，816名参与者，其中25，466人在随访期间死于自然原因（平均随访时间为14.3年）。几乎所有元素的风险比均为阳性，PM2.5硫的风险比具有统计学意义（1.14; 95% CI：1.06，1.23/200 ng/m3）。在双污染物模型中，与PM2.5硫的关联对于PM2.5质量的调整是稳健的，而与PM2.5质量的关联被降低。长期暴露于PM2.5硫与自然原因死亡率相关。这种关联对于其他污染物和PM2.5的调整是稳健的。比伦R，Hoek G，Raaschou-Nielsen O，Stafoggia M，Andersen ZJ，Weinmayr G，Hoffmann B，Wolf K，Samoli E，Fischer PH，Nieuwenhuijsen MJ，Xun WW，Katsouyanni K，Dimakopoulou K，Marcon A，Vartiainen E，Lanki T，Yli-Tuomi T，Oftedal B，Schwarze PE，Nafstad P，De Faire U，Pedersen NL，Östenson C-G，Fratiglioni L，Penell J，Korek M，Pershagen G，Eriksen KT，Overvad K，Sørensen M，Eeftens M，Peeters PH，Meliefste K，Wang M，Bueno-de-Mesquita HB，Sugiri D，Krämer U，Heinrich J，de Hoogh K，Key T，Peters A，Hampel R，Concin H，内格尔G，Jaensch A，Ineichen A，Tsai MY，Schaffner E，Probst-Hensch NM，Schindler C，Ragettli MS，Vilier A，Clavel-Chapelon F，Declercq C，Ricceri F，Sacerdote C，Galassi C，Migliore E，Ranzi A，Cesaroni G，Badaloni C，Forastiere F，Katsoulis M，Trichopoulou A，Keuken M，Jedynska A，Kooter IM，Kukkonen J，Sokhi RS，Vineis P，Brunekreef B. 2015.自然原因死亡率和长期暴露于颗粒成分：多中心ESCAPE项目中19个欧洲队列的分析。环境健康展望123：525-533; http：dx.doi.org/10.1289/ehp.1408095
Studies have shown associations between mortality and long-term exposure to particulate matter air pollution. Few cohort studies have estimated the effects of the elemental composition of particulate matter on mortality. Our aim was to study the association between natural-cause mortality and long-term exposure to elemental components of particulate matter. Mortality and confounder data from 19 European cohort studies were used. Residential exposure to eight a priori–selected components of particulate matter (PM) was characterized following a strictly standardized protocol. Annual average concentrations of copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc within PM size fractions ≤ 2.5 μm (PM2.5) and ≤ 10 μm (PM10) were estimated using land-use regression models. Cohort-specific statistical analyses of the associations between mortality and air pollution were conducted using Cox proportional hazards models using a common protocol followed by meta-analysis. The total study population consisted of 291,816 participants, of whom 25,466 died from a natural cause during follow-up (average time of follow-up, 14.3 years). Hazard ratios were positive for almost all elements and statistically significant for PM2.5 sulfur (1.14; 95% CI: 1.06, 1.23 per 200 ng/m3). In a two-pollutant model, the association with PM2.5 sulfur was robust to adjustment for PM2.5 mass, whereas the association with PM2.5 mass was reduced. Long-term exposure to PM2.5 sulfur was associated with natural-cause mortality. This association was robust to adjustment for other pollutants and PM2.5. Beelen R, Hoek G, Raaschou-Nielsen O, Stafoggia M, Andersen ZJ, Weinmayr G, Hoffmann B, Wolf K, Samoli E, Fischer PH, Nieuwenhuijsen MJ, Xun WW, Katsouyanni K, Dimakopoulou K, Marcon A, Vartiainen E, Lanki T, Yli-Tuomi T, Oftedal B, Schwarze PE, Nafstad P, De Faire U, Pedersen NL, Östenson C-G, Fratiglioni L, Penell J, Korek M, Pershagen G, Eriksen KT, Overvad K, Sørensen M, Eeftens M, Peeters PH, Meliefste K, Wang M, Bueno-de-Mesquita HB, Sugiri D, Krämer U, Heinrich J, de Hoogh K, Key T, Peters A, Hampel R, Concin H, Nagel G, Jaensch A, Ineichen A, Tsai MY, Schaffner E, Probst-Hensch NM, Schindler C, Ragettli MS, Vilier A, Clavel-Chapelon F, Declercq C, Ricceri F, Sacerdote C, Galassi C, Migliore E, Ranzi A, Cesaroni G, Badaloni C, Forastiere F, Katsoulis M, Trichopoulou A, Keuken M, Jedynska A, Kooter IM, Kukkonen J, Sokhi RS, Vineis P, Brunekreef B. 2015. Natural-cause mortality and long-term exposure to particle components: an analysis of 19 European cohorts within the Multi-Center ESCAPE Project. Environ Health Perspect 123:525–533; http://dx.doi.org/10.1289/ehp.1408095
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影响因子：
2
作者：
Thiébaut, ACM;Bénichou, J
通讯作者：
Bénichou, J
影响因子：
168.9
作者：
Smith, Kirk R.;Jerrett, Michael;Anderson, H. Ross;Burnett, Richard T.;Stone, Vicki;Derwent, Richard;Atkinson, Richard W.;Cohen, Aaron;Shonkoff, Seth B.;Krewski, Daniel;Pope, C. Arden, III;Thun, Michael J.;Thurston, George
通讯作者：
Thurston, George
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
0.5
作者：
Agarwal, Neil K.;Sharma, Prerna;Agarwal, Shashi K.
通讯作者：
Agarwal, Shashi K.
影响因子：
168.9
作者：
Beelen, Rob;Raaschou-Nielsen, Ole;Hoek, Gerard
通讯作者：
Hoek, Gerard