Human cytomegalovirus reinfection is associated with intrauterine transmission in a highly cytomegalovirus-immune maternal population.
Human cytomegalovirus reinfection is associated with intrauterine transmission in a highly cytomegalovirus-immune maternal population.
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DOI：
10.1016/j.ajog.2009.11.018
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发表时间：
2010-03
影响因子：
9.8
通讯作者：
Britt WJ
中科院分区：
文献类型：
--
作者：
Yamamoto AY;Mussi-Pinhata MM;Boppana SB;Novak Z;Wagatsuma VM;Oliveira Pde F;Duarte G;Britt WJ
确定巨细胞病毒血清免疫妇女巨细胞病毒新毒株再感染对先天性巨细胞病毒感染发病率的影响。在7848名先天性巨细胞病毒感染的妇女中进行了前瞻性研究，这些妇女来自于一个几乎具有普遍巨细胞病毒血清免疫的人群，对40名先天性感染婴儿的母亲和109名未感染新生儿的母亲的血清进行了株特异性抗巨细胞病毒抗体分析。所有妇女在第一次产前检查时都有巨细胞病毒血清免疫。在首次产前访视时，40名研究母亲中有14名和109名对照母亲中有17名发现2种巨细胞病毒株的反应性（P = .009）。40名研究妇女中有7名（17.5%）和109名对照妇女中有5名（4.6%）（P = 0.002）在妊娠期间获得了与新的巨细胞病毒株反应的抗体。40名研究母亲中有21名在妊娠前或妊娠期间感染了一种以上的巨细胞病毒，109名对照母亲中有22名感染了巨细胞病毒（P < .0001）。母亲再次感染新株巨细胞病毒是该人群先天性感染的主要来源。
To determine contribution of reinfection with new strains of cytomegalovirus in cytomegalovirus seromimmune women to incidence of congenital cytomegalovirus infection. In 7848 women studied prospectively for congenital cytomegalovirus infection from a population with near universal cytomegalovirus seroimmunity, sera from 40 mothers of congenitally infected infants and 109 mothers of uninfected newborns were analyzed for strain-specific anticytomegalovirus antibodies. All women were cytomegalovirus seroimmune at first prenatal visit. Reactivity for 2 cytomegalovirus strains was found in 14 of 40 study mothers and in 17 of 109 control mothers at first prenatal visit (P = .009). Seven of 40 (17.5%) study women and 5 of 109 (4.6%) controls (P = .002) acquired antibodies reactive with new cytomegalovirus strains during pregnancy. Evidence of infection with more than 1 strain of cytomegalovirus before or during current pregnancy occurred in 21 of 40 study mothers and 22 of 109 controls (P < .0001). Maternal reinfection by new strains of cytomegalovirus is a major source of congenital infection in this population.
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影响因子：
3.8
作者：
Burkhardt, Christiane;Himmelein, Susanne;Mach, Michael
通讯作者：
Mach, Michael
影响因子：
3.6
作者：
BOPPANA, SB;PASS, RF;ALFORD, CA
通讯作者：
ALFORD, CA
影响因子：
5.1
作者：
Bale, JF;Petheram, SJ;Murph, JR
通讯作者：
Murph, JR
影响因子：
12.7
作者：
Bradley, Amanda J.;Kovacs, Ida J.;Gatherer, Derek;Dargan, Derrick J.;Alkharsah, Khaled R.;Chan, Paul K. S.;Carman, William F.;Dedicoat, Martin;Emery, Vincent C.;Geddes, Colin C.;Gerna, Giuseppe;Ben-Ismaeil, Bassam;Kaye, Steve;McGregor, Alistair;Moss, Paul A.;Pusztai, Rozalia;Rawlinson, William D.;Scott, Gillian M.;Wilkinson, Gavin W. G.;Schulz, Thomas F.;Davison, Andrew J.
通讯作者：
Davison, Andrew J.
影响因子：
6.4
作者：
CHANDLER, SH;HANDSFIELD, HH;MCDOUGALL, JK
通讯作者：
MCDOUGALL, JK