Brain regulation of appetite and satiety.

Brain regulation of appetite and satiety.
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DOI:
10.1016/j.ecl.2008.08.005
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发表时间:
2008-12
影响因子:
4.5
通讯作者:
Antwi, Daniel A.
Antwi, Daniel A.
中科院分区:
医学2区
文献类型:
--
作者:
Ahima, Rexford S.;Antwi, Daniel A.

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Interest in the control feeding and has increased as a result of the obesity epidemic and rising incidence of metabolic diseases. The brain detects alterations in energy stores and triggers metabolic and behavioral responses designed to maintain energy balance. Energy homeostasis is controlled mainly by neuronal circuits in the hypothalamus and brainstem, whereas reward and motivation aspects of eating behavior are controlled by neurons in limbic regions and cerebral cortex. This article provides an integrated perspective on how metabolic signals emanating from the gastrointestinal tract, adipose tissue and other peripheral organs target the brain to regulate feeding, energy expenditure and hormones. Knowledge of these complex pathways is crucial to the pathogenesis and treatment of obesity and abnormalities of glucose and lipid metabolism.
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