The genetic influence on radiographic osteoarthritis is site specific at the hand, hip and knee.
The genetic influence on radiographic osteoarthritis is site specific at the hand, hip and knee.
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DOI：
10.1093/rheumatology/ken475
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发表时间：
2009-03
期刊：
影响因子：
--
通讯作者：
Williams FM
中科院分区：
文献类型：
--
作者：
MacGregor AJ;Li Q;Spector TD;Williams FM
目标。确定在不同骨骼部位是否存在共同的遗传影响导致OA的发生。方法。对来自TwinsUK注册中心的992名同卵和异卵女性双胞胎参与者的手（DIP、PIP和CMC关节）、髋关节和膝关节的常见放射学OA数据进行多变量建模。结果。所有五个关节部位的骨关节炎都是遗传性的。遗传影响与手部关节密切相关；然而，很少有证据表明有共同的遗传途径来解释手、髋和膝关节关节炎的共同发生。结论。虽然遗传影响在解释手、髋和膝关节骨性关节炎发生的差异方面很重要，但没有证据表明共同或共有的遗传因素决定了所有这些骨骼部位的疾病发生。研究结果表明，在女性中有重要的病因学差异，这是部位特异性的。这些结果对研究骨性关节炎的遗传基础以及预防和治疗骨性关节炎的策略的设计具有启示意义。
Objective. To identify whether a shared genetic influence accounts for the occurrence of OA at different skeletal sites. Methods. Multivariate modelling of data on prevalent radiographic OA at the hand (DIP, PIP and CMC joints), hip and knee joints assessed in 992 monozygotic and dizygotic female twin participants from the TwinsUK Registry. Results. OA at all the five joint sites was heritable. Genetic influences were strongly correlated among joints in the hand; however, there was little evidence of common genetic pathways to account for the co-occurrence of OA at the hand, hip and knee. Conclusions. While genetic influences are important in explaining the variation in occurrence of OA at the hand, hip and knee, there is no evidence that common or shared genetic factors determine the occurrence of disease across all these skeletal sites. The findings suggest that there are important aetiological differences in the disease that are site-specific in women. These results have implications for the design of studies examining the genetic basis of OA as well as for strategies aimed at preventing and treating the disease.
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影响因子：
7.2
作者：
Stürmer, T;Günther, KP;Brenner, H
通讯作者：
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影响因子：
7
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6.2
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通讯作者：
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影响因子：
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影响因子：
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作者：
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通讯作者：
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