Is there a higher prevalence of human papillomavirus infection in Chinese laryngeal cancer patients? A systematic review and meta-analysis
Is there a higher prevalence of human papillomavirus infection in Chinese laryngeal cancer patients? A systematic review and meta-analysis
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中国喉癌患者人乳头瘤病毒感染率是否较高？
DOI：
10.1007/s00405-014-3345-3
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发表时间：
2016-02
影响因子：
2.6
通讯作者：
Xie Minqiang
中科院分区：
文献类型：
--
作者：
Zhang Chunlin;Deng Zeyi;Chen Yuehong;Suzuki Mikio;Xie Minqiang
越来越多的证据表明，持续的人乳头瘤病毒（HPV）感染与某些类型的头颈部鳞状细胞癌（包括喉癌）的风险密切相关。一些报告表明中国LC患者中HPV的患病率较高，由于研究样本量较小，这一点仍有待确定。本研究的目的是估计中国LC患者中HPV感染率，并通过荟萃分析评估高危亚型HPV感染对LC的风险。检索MEDLINE、Embase数据库、中国知网、万方数据库、维普数据库，并检索截至2013年10月的中英文文献，对符合纳入标准的28篇原始文献进行系统回顾。采用R3.0软件对LC组（全部28项研究）的HPV感染率和高危型HPV感染（12项病例对照研究的亚组）的LC风险进行分析。总体HPV、HPV-16/18和HPV-6/11感染率分别为32%（95%CI 22- 44%）、30%（95%CI 24- 37%）和12%（95%CI 9- 17%）。高危型HPV-16/18感染与LC的发生密切相关（P< 0.01; OR = 8.07，95%CI 5.67-11.48）。我们的研究表明，与中国以外的LC患者相比，中国LC患者的HPV患病率较高，HPV感染显著增加LC风险。
Accumulating evidence suggests that persistent human papillomavirus (HPV) infection is closely related to the risk of certain types of head and neck squamous cell carcinoma types, including laryngeal cancer (LC). Some reports indicated a higher HPV prevalence in Chinese LC patients, which remains to be established due to small study sample sizes. The aim of this study was to estimate the HPV infection rate in Chinese LC patients and assess the LC risk conferred by high-risk subtype HPV infection by meta-analysis. We searched MEDLINE, the Embase Database, Chinese National Knowledge Infrastructure, Wanfang Database, and VIP Database for studies published in either English or Chinese up to October 2013, and systematically reviewed 28 original research articles that met the inclusion criteria. Both the HPV infection rate in the LC group (all 28 studies) and the LC risk from high-risk HPV infection (a subgroup of 12 case–control studies) were analyzed by R 3.0 software. Overall HPV, HPV-16/18, and HPV-6/11 infection rates were 32 % (95 % CI 22–44 %), 30 % (95 % CI 24–37 %), and 12 % (95 % CI 9–17 %), respectively. There was a strong association between high-risk HPV-16/18 infection and LC (P< 0.01; OR = 8.07, 95 % CI 5.67–11.48). Our research indicates that there is a higher HPV prevalence in Chinese LC patients compared to LC patients outside of China and that HPV infection significantly increases LC risk.
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DOI：
10.1016/j.yoto.2012.01.016
发表时间：
2012
期刊：
Yearbook of Otolaryngology-head and Neck Surgery
影响因子：
--
作者：
M. Gapany
通讯作者：
M. Gapany
影响因子：
8
作者：
Block, Stan L.;Nolan, Terry;Reisinger, Keith S.
通讯作者：
Reisinger, Keith S.
影响因子：
12.7
作者：
Y. Furuta;S. Fukuda;E. Chida;T. Takasu;F. Ohtani;Y. Inuyama;K. Nagashima
通讯作者：
Y. Furuta;S. Fukuda;E. Chida;T. Takasu;F. Ohtani;Y. Inuyama;K. Nagashima
影响因子：
1.7
作者：
Gungor, A.;Cincik, H.;Dursun, E.
通讯作者：
Dursun, E.
影响因子：
4.5
作者：
Li, Wei;Tran, Nham;Rose, Barbara R.
通讯作者：
Rose, Barbara R.