Assessment of particulate matter toxicity and physicochemistry at the Claim 28 uranium mine site in Blue Gap, AZ.
Assessment of particulate matter toxicity and physicochemistry at the Claim 28 uranium mine site in Blue Gap, AZ.
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亚利桑那州Blue Gap的Claim28铀矿矿场颗粒物毒性和物理化学的评估。
DOI：
10.1080/15287394.2020.1830210
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发表时间：
2021-01-02
期刊：
影响因子：
--
通讯作者：
Campen MJ
中科院分区：
文献类型：
--
作者：
Begay J;Sanchez B;Wheeler A;Baldwin F Jr;Lucas S;Herbert G;Ordonez Suarez Y;Shuey C;Klaver Z;Harkema JR;Wagner JG;Morishita M;Bleske B;Zychowski KE;Campen MJ
美国西部有数千个废弃的铀矿（AUM）。由于不适当的补救措施，从AUM产生的扬尘是重大的社区关注。移动的吸入实验室位于高度社区关注的AUM附近（“权利要求28”），具有三个主要目的：（1）确定区域环境颗粒物（PM）的组成，（2）评估气象特征（风速和风向），和（3）评估小鼠在暴露于浓缩的环境PM（或CAP）后的免疫和生理反应。将C57 BL/6和载脂蛋白E-缺失（ApoE-/-）小鼠暴露于位于权利要求28的SW约1 km处的AirCARE 1中的CAP，以约80 μg/m3 CAP持续1天或28天，持续4小时/天。支气管肺泡灌洗液（BALF）分析显示，C57 BL/6小鼠暴露一天后，中性粒细胞大量流入（平均PM2.5浓度= 68μg/m3）。与过滤空气（FA）相比，CAP暴露组中暴露1天的小鼠肺显示Tnfa和Tgfb mRNA水平适度增加。暴露28天的小鼠肺显示Tgfb（C57 BL/6）和Tnfa（ApoE−/−）mRNA水平降低。风向通常从西南向东北移动（远离社区），虽然在所有样本中均可检测到，但PM2.5部分中的铀浓度与已报告的值没有明显差异。总的来说，在Blue Gap Tachee的Claim-28铀矿区接触CAPs几乎没有证据表明铀或钒造成明显的肺损伤或炎症或环境空气污染。
Thousands of abandoned uranium mines (AUMs) exist in the western United States. Due to improper remediation, windblown dusts generated from AUMs are of significant community concern. A mobile inhalation lab was sited near an AUM of high community concern (“Claim 28”) with three primary objectives: to (1) determine the composition of the regional ambient particulate matter (PM), (2) assess meteorological characteristics (wind speed and direction), and (3) assess immunological and physiological responses of mice after exposures to concentrated ambient PM (or CAPs). C57BL/6 and apolipoprotein E-null (ApoE−/−) mice were exposed to CAPs in AirCARE1 located approximately 1 km to the SW of Claim 28, for 1 or 28 days for 4 hr/day at approximately 80 μg/m3 CAPs. Bronchoalveolar lavage fluid (BALF) analysis revealed a significant influx of neutrophils after a single day exposure in C57BL/6 mice (average PM2.5 concentration = 68μg/m3). Lungs from mice exposed for 1 day exhibited modest increases in Tnfa and Tgfb mRNA levels in the CAPs exposure group compared to filtered air (FA). Lungs from mice exposed for 28 days exhibited reduced Tgfb (C57BL/6) and Tnfa (ApoE−/−) mRNA levels. Wind direction was typically moving from SW to NE (away from the community) and, while detectable in all samples, uranium concentrations in the PM2.5 fraction were not markedly different from published-reported values. Overall, exposure to CAPs in the region of the Blue Gap Tachee’s Claim-28 uranium mine demonstrated little evidence of overt pulmonary injury or inflammation or ambient air contamination attributed to uranium or vanadium.
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影响因子：
120.7
作者：
Dwyer-Lindgren, Laura;Bertozzi-Villa, Amelia;Murray, Christopher J. L.
通讯作者：
Murray, Christopher J. L.
DOI：
10.1080/15287394.2016.1222920
发表时间：
2017
期刊：
Journal of toxicology and environmental health. Part A
影响因子：
--
作者：
Castañeda AR;Bein KJ;Smiley-Jewell S;Pinkerton KE
通讯作者：
Pinkerton KE
影响因子：
3.8
作者：
Campen, Matthew J.;Lund, Amie K.;McDonald, Jacob D.
通讯作者：
McDonald, Jacob D.
在长期暴露的纳瓦霍族社区中，住宅邻近地靠近废弃的铀矿和血清炎症潜力。
影响因子：
4.5
作者：
Harmon ME;Lewis J;Miller C;Hoover J;Ali AS;Shuey C;Cajero M;Lucas S;Zychowski K;Pacheco B;Erdei E;Ramone S;Nez T;Gonzales M;Campen MJ
通讯作者：
Campen MJ
美国健康效应研究中PM（2.5）化学成分的空间和时间变化。
影响因子：
10.4
作者：
Bell ML;Dominici F;Ebisu K;Zeger SL;Samet JM
通讯作者：
Samet JM