Residential proximity to abandoned uranium mines and serum inflammatory potential in chronically exposed Navajo communities.
Residential proximity to abandoned uranium mines and serum inflammatory potential in chronically exposed Navajo communities.
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在长期暴露的纳瓦霍族社区中，住宅邻近地靠近废弃的铀矿和血清炎症潜力。
DOI：
10.1038/jes.2016.79
复制
发表时间：
2017-07
影响因子：
4.5
通讯作者：
Campen MJ
中科院分区：
文献类型：
--
作者：
Harmon ME;Lewis J;Miller C;Hoover J;Ali AS;Shuey C;Cajero M;Lucas S;Zychowski K;Pacheco B;Erdei E;Ramone S;Nez T;Gonzales M;Campen MJ
纳瓦霍族的成员心脏代谢疾病发病率很高，他们居住在数百个当地废弃的铀矿附近，这些铀矿向土壤、水和空气中提供铀、砷和其他金属。我们最近报道，高血压与这一人群的矿山废物暴露有关。炎症是许多血管疾病发展的主要参与者。我们先前的工作建立了用人血清处理的培养内皮细胞的特异性转录反应可以以响应污染物暴露的方式揭示相对循环炎症潜力，提供了一个模型来评估与暴露于这些废物相关的反应。为了研究受影响社区中暴露于AUM和血清炎症潜力之间的潜在联系，用Navajo研究参与者（n = 145）提供的血清处理原代人冠状动脉内皮细胞4小时。测定内皮细胞间粘附分子-1（ICAM-1）、血管细胞粘附分子-1（VCAM-1）和趋化因子配体2（CCL 2）的转录反应。然后将这些转录反应与AUM暴露指标联系起来，包括表面积加权的AUM接近度和估计的金属口服摄入量。AUM接近强烈预测内皮细胞对血清的转录反应，包括CCL 2，VCAM-1和ICAM-1（P < 0.0001），而砷和铀的年饮水量没有，即使在控制所有主要的效应调节剂。与接近AUM相关的潜在炎症，而不是特定金属的口服摄入，另外表明吸入暴露作为心血管疾病的贡献者的作用。
Members of the Navajo Nation, who possess a high prevalence of cardiometabolic disease, reside near hundreds of local abandoned uranium mines (AUM), which contribute uranium, arsenic and other metals to the soil, water and air. We recently reported that hypertension is associated with mine waste exposures in this population. Inflammation is a major player in the development of numerous vascular ailments. Our previous work establishing that specific transcriptional responses of cultured endothelial cells treated with human serum can reveal relative circulating inflammatory potential in a manner responsive to pollutant exposures, providing a model to assess responses associated with exposure to these waste materials in this population. To investigate a potential link between exposures to AUM and serum inflammatory potential in affected communities, primary human coronary artery endothelial cells were treated for 4 h with serum provided by Navajo study participants (n = 145). Endothelial transcriptional responses of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and chemokine ligand 2 (CCL2) were measured. These transcriptional responses were then linked to AUM exposure metrics, including surface area-weighted AUM proximity and estimated oral intake of metals. AUM proximity strongly predicted endothelial transcriptional responses to serum including CCL2, VCAM-1 and ICAM-1 (P < 0.0001 for each), whereas annual water intakes of arsenic and uranium did not, even after controlling for all major effect modifiers. Inflammatory potential associated with proximity to AUMs, but not oral intake of specific metals, additionally suggests a role for inhalation exposure as a contributor to cardiovascular disease.
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DOI：
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发表时间：
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影响因子：
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