Studies on the liver to kidney switch of erythropoietin production.
Studies on the liver to kidney switch of erythropoietin production.
复制标题
促红细胞生成素产生的肝脏至肾脏转换的研究。
DOI：
10.1172/jci110133
复制
发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Ash,RC
中科院分区：
文献类型：
--
作者：
Zanjani,ED;Ascensao,JL;McGlave,PB;Banisadre,M;Ash,RC
虽然肝脏是胎儿产生促红细胞生成素 (Ep) 的主要场所，但成人的此功能由肾脏承担。 Ep 形成从肝脏到肾脏转换的机制尚不清楚。我们通过测量正常和双侧肾切除的胎儿和新生羊从妊娠约 80 天（正常妊娠：140 天）开始的贫血反应，研究了绵羊中这种转变的自然进展。在诱发贫血之前切除双肾并不影响妊娠 120 天左右的 Ep 形成。在妊娠第 130 天左右（转换开始），首次发现 Ep 合成显着减少（29%，P<0.02）。这种肾切除术引起的 Ep 形成减少持续到出生后约 15 天。此后，双侧肾切除术导致 Ep 产生进一步显着下降（P < 0.05），逐渐导致产后 40 天左右几乎完全没有 Ep 产生（转换完成）。从妊娠85-90天开始对胎儿/新生儿长期服用睾酮（12毫克/周）或苯甲酸雌二醇（1.5毫克/天，5天/周）分别增强或抑制红细胞生成，但未能影响肝脏到肾脏转换开始和/或完成的时间。相比之下，在甲状腺切除或从妊娠期后三分之一开始出现慢性贫血的动物中，转变发生显着延迟（P<0.001），但未完成。对甲状腺切除的胎儿/新生儿施用甲状腺素（1.2 mg/d，5 d/wk）不仅可以防止转换启动的延迟，而且还可以加快转换完成的速度。这些结果表明，在绵羊中，(a) Ep 产生的肝脏到肾脏的转换在妊娠期的最后三分之一的子宫内开始，但在出生后完成，(b) 这种转变逐渐发生；假设肾脏产生 Ep 的能力并未出现肝脏 Ep 形成的突然丧失； (c)这种转换不受产前-产后生长期性激素水平变化的影响，但深受甲状腺激素和氧气供需水平变化的影响。
Although the liver is the major site of erythropoietin (Ep) production in the fetus, this function is assumed by kidneys in the adult. The mechanisms underlying the liver to kidney switch of Ep formation are not understood. We studied the natural progression of this transition in sheep by measuring Ep production in response to anemia in normal and bilaterally nephrectomized fetal and newborn sheep beginning at about 80 d gestation (normal gestation: 140 d). Removal of both kidneys before induction of anemia did not affect Ep formation up to about 120 d of gestation. A significant reduction (29%,P< 0.02) in Ep synthesis was first noted at about 130 d of gestation (initiation of switch). This level of nephrectomy-induced reduction of Ep formation persisted until about 15 d after birth. Thereafter, bilateral nephrectomy caused further significant decreases (P< 0.05) in Ep production, gradually resulting in near total absence of Ep production at about day 40 postpartum (completion of switch). Chronic administration of testosterone (12 mg/wk) or estradiole benzoate (1.5 mg/d, 5 d/wk) to the fetus/newborn beginning at 85-90 d of gestation enhanced or suppressed erythropoiesis, respectively, but failed to affect the time at which the liver to kidney switch was initiated and/or completed. By contrast, a significant delay (P< 0.001) in the onset, but not completion of the switch occurred in animals that were either thyroidectomized or rendered chronically anemic beginning in the second third of the gestation period. Administration of thyroxin (1.2 mg/d, 5 d/wk) to thyroidectomized fetus/newborns not only prevented the delay in the initiation of the switch, but also accelerated the rate at which the switch was completed. These results demonstrate that in sheep (a) the liver to kidney switch of Ep production is initiatedin uteroduring the last third of the gestation period, but is completed after birth, (b) this transition occurs gradually; the assumption of Ep producing capacity by the kidney is not preceded by an abrupt loss of hepatic Ep formation; and (c) the switch is not affected by changes in sex hormone levels during the prenatal-postnatal growth periods, but is profoundly influenced by alterations in thyroid hormone and oxygen supply-demand levels.
登录
查看更多内容
贫血大鼠肾内和肾外促红细胞生成素的产生
影响因子：
6.5
作者：
A. Erslev;J. Caro;E. Kansu;R. Silver
通讯作者：
R. Silver
胎儿促红细胞生成素的产生：肾脏的作用和母体贫血。
DOI：
--
发表时间：
1974
期刊：
Journal of Laboratory and Clinical Medicine
影响因子：
--
作者：
E. Zanjani;Peterson En;A. S. Gordon;L. Wasserman
通讯作者：
L. Wasserman
无肾羊胎儿促红细胞生成素产生和红细胞生成的激素刺激。
影响因子：
15.9
作者：
E. Zanjani;M. Banisadre
通讯作者：
M. Banisadre
胎儿和新生儿红细胞生成*
影响因子：
5.2
作者：
G. Lucarelli;A. Porcellini;C. Carnevali;A. Carmena;F. Stohlman
通讯作者：
F. Stohlman
胎羔中促红细胞生成素的产生。
DOI：
--
发表时间：
1969
期刊：
Journal of Laboratory and Clinical Medicine
影响因子：
--
作者：
E. Zanjani;E. O. Horger;A. S. Gordon;L. Cantor;D. L. Hutchinson
通讯作者：
D. L. Hutchinson