The development of a normalization method for comparing nerve regeneration effectiveness among different graft types.
The development of a normalization method for comparing nerve regeneration effectiveness among different graft types.
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DOI：
10.1111/jns5.12043
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发表时间：
2013-12
期刊：
影响因子：
--
通讯作者：
Yu X
中科院分区：
文献类型：
--
作者：
Chang W;DeVince J;Green G;Shah MB;Johns MS;Meng Y;Yu X
无法直接比较不同的神经移植物一直是阻碍神经移植物发展的重要因素。由于神经移植物结构中存在丰富的变量和多种评估类型，在实验中比较神经移植物有效性的成功有限。对神经传导速度（NCV）自体移植数据使用数学技术，根据经验推导出归一化函数，该归一化函数将间隙长度的差异归一化。进一步分析允许开发相对再生率（RRR）。RRR功能允许研究人员根据各自研究的NCV数据直接比较神经移植结果，只要数据是在相同的术后时间收集的。该功能还允许在不同间隙长度下测试的移植物之间进行比较。该RRR函数的初始测试提供了该函数对于连续间隙长度和不同神经移植物类型的准确性的信心。
The inability to compare directly different nerve grafts has been a significant factor hindering the advance of nerve graft development. Due to the abundance of variables that exist in nerve graft construction and multiple assessment types, there has been limited success in comparing nerve graft effectiveness among experiments. Using mathematical techniques on nerve conduction velocity (NCV) autograft data, a normalization function was empirically derived that normalizes differences in gap lengths. Further analysis allowed for the development of the Relative Regeneration Ratio (RRR). The RRR function allows researchers to directly compare nerve graft results based on the NCV data from their respective studies as long as the data was collected at the same post-operation time. This function also allows for comparisons between grafts tested at different gap lengths. Initial testing of this RRR function provided confidence that the function is accurate for a continuum of gap lengths and different nerve graft types.
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