Somatosensory activation of two fingers can be discriminated with ultrahigh-density diffuse optical tomography.
Somatosensory activation of two fingers can be discriminated with ultrahigh-density diffuse optical tomography.
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DOI：
10.1016/j.neuroimage.2011.11.062
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发表时间：
2012-02-15
期刊：
影响因子：
5.7
通讯作者：
Schmitz, Christoph H.
中科院分区：
文献类型：
--
作者：
Habermehl, Christina;Holtze, Susanne;Steinbrink, Jens;Koch, Stefan P.;Obrig, Hellmuth;Mehnert, Jan;Schmitz, Christoph H.
关键词：
近红外光谱技术（NIRS）是一种非侵入性的脑功能成像技术。在受试者的头部上应用多达100个光极，允许实现厘米范围内的空间分辨率。与其他功能成像工具相比，该分辨率较差。然而，最近，它被证明，扩散光学断层扫描（DOT）作为近红外光谱的基础上高密度（HD）探头阵列的扩展，并辅以先进的图像重建程序允许描述激活模式的空间分辨率在毫米范围内。基于这些发现，我们假设HD-DOT可能会使非常局灶性的激活变得容易，而传统上使用的稀疏阵列会错过这些激活。我们研究了初级躯体感觉皮层的激活模式，因为它的躯体组织是非常细粒度的。我们进行了一个振动触觉刺激研究的第一和第五指在8个人类受试者，使用900通道连续波DOT成像系统，实现了比传统的地形近红外光谱更高的分辨率。为了将结果与成熟的高分辨率成像技术进行比较，通过功能性磁共振成像（fMRI）在相同的受试者中研究了相同的范例。在这项工作中，我们测试了超高密度探针阵列的优势，并表明当使用稀疏探针阵列时，经典的次近邻NIRS方法以及DOT都会错过高焦点激活。在8名受试者中，有5名受试者的两个手指的不同激活模式与预期的神经解剖结构相关。此外，我们表明，激活不同的手指投影到不同的组织深度的DOT图像。在这5名受试者中，当比较DOT和fMRI结果的侧向定位时，与fMRI数据的比较在十分之七的手指表征中产生了相似的激活灶。
Topographic non-invasive near infrared spectroscopy (NIRS) has become a well-established tool for functional brain imaging. Applying up to 100 optodes over the head of a subject, allows achieving a spatial resolution in the centimeter range. This resolution is poor compared to other functional imaging tools. However, recently it was shown that diffuse optical tomography (DOT) as an extension of NIRS based on high-density (HD) probe arrays and supplemented by an advanced image reconstruction procedure allows describing activation patterns with a spatial resolution in the millimeter range. Building on these findings, we hypothesize that HD-DOT may render very focal activations accessible which would be missed by the traditionally used sparse arrays. We examined activation patterns in the primary somato-sensory cortex, since its somatotopic organization is very fine-grained. We performed a vibrotactile stimulation study of the first and fifth finger in eight human subjects, using a 900-channel continuous-wave DOT imaging system for achieving a higher resolution than conventional topographic NIRS. To compare the results to a well established high-resolution imaging technique, the same paradigm was investigated in the same subjects by means of functional magnetic resonance imaging (fMRI). In this work, we tested the advantage of ultrahigh-density probe arrays and show that highly focal activations would be missed by classical next-nearest neighbor NIRS-approach, but also by DOT, when using a sparse probe array. Distinct activation patterns for both fingers correlated well with the expected neuro-anatomy in five of eight subjects. Additionally we show that activation for different fingers are projected to different tissue depths in the DOT image. Comparison to the fMRI data yielded similar activation foci in seven out of ten finger representations in these five subjects when comparing the lateral localization of DOT and fMRI results.
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影响因子：
--
作者：
Dehghani, Hamid;Eames, Matthew E.;Yalavarthy, Phaneendra K.;Davis, Scott C.;Srinivasan, Subhadra;Carpenter, Colin M.;Pogue, Brian W.;Paulsen, Keith D.
通讯作者：
Paulsen, Keith D.
影响因子：
1.9
作者：
Dehghani H;White BR;Zeff BW;Tizzard A;Culver JP
通讯作者：
Culver JP
影响因子：
5.7
作者：
FRISTON, KJ;HOLMES, AP;TURNER, R
通讯作者：
TURNER, R
DOI：
10.1073/pnas.83.4.1140
发表时间：
1986-02-01
影响因子：
11.1
作者：
FOX, PT;RAICHLE, ME
通讯作者：
RAICHLE, ME
影响因子：
1.9
作者：
Joseph, Danny K.;Huppert, Theodore J.;Boas, David A.
通讯作者：
Boas, David A.