Auraptene Acts as an Anti-Inflammatory Agent in the Mouse Brain.
Auraptene Acts as an Anti-Inflammatory Agent in the Mouse Brain.
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DOI：
10.3390/molecules201119691
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发表时间：
2015-11-10
期刊：
影响因子：
--
通讯作者：
Furukawa Y
中科院分区：
文献类型：
--
作者：
Okuyama S;Morita M;Kaji M;Amakura Y;Yoshimura M;Shimamoto K;Ookido Y;Nakajima M;Furukawa Y
auraptene（AUR），一种柑橘香豆素，在外周组织中的抗炎活性是众所周知的，我们以前证明了AUR在缺血性脑中发挥抗炎作用;在缺血性手术后立即用AUR治疗小鼠8天抑制海马中的死亡和神经元细胞死亡，可能是通过其在脑中的抗炎作用。我们认为这些作用至少部分是通过抑制星形胶质细胞的炎症介质介导的。本研究结果表明：（1）AUR预处理缺血前5d和缺血后3d，可抑制小胶质细胞活化、星形胶质细胞环氧合酶（考克斯）-2表达和海马考克斯-2mRNA表达，（2）AUR可抑制脂多糖诱导的星形胶质细胞考克斯-2mRNA和促炎细胞因子mRNA表达;（3）腹腔注射后60 min，脑内仍能检测到AUR。这些结果支持了我们先前的建议，即AUR直接对大脑发挥抗炎作用。
The anti-inflammatory activity of auraptene (AUR), a citrus coumarin, in peripheral tissues is well-known, and we previously demonstrated that AUR exerts anti-inflammatory effects in the ischemic brain; the treatment of mice with AUR for eight days immediately after ischemic surgery suppressed demise and neuronal cell death in the hippocampus, possibly through its anti-inflammatory effects in the brain. We suggested that these effects were at least partly mediated by the suppression of inflammatory mediators derived from astrocytes. The present study showed that (1) AUR, as a pretreatment for five days before and another three days after ischemic surgery, suppressed microglial activation, cyclooxygenase (COX)-2 expression in astrocytes, and COX-2 mRNA expression in the hippocampus; (2) AUR suppressed the lipopolysaccharide-induced expression of COX-2 mRNA and the mRNA of pro-inflammatory cytokines in cultured astrocytes; (3) AUR was still detectable in the brain 60 min after its intraperitoneal administration. These results support our previous suggestion that AUR directly exerts anti-inflammatory effects on the brain.
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DOI：
10.1155/2014/408503
发表时间：
2014
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Okuyama S;Yamamoto K;Mori H;Toyoda N;Yoshimura M;Amakura Y;Yoshida T;Sugawara K;Sudo M;Nakajima M;Furukawa Y
通讯作者：
Furukawa Y
影响因子：
8.3
作者：
Ito, D;Tanaka, K;Fukuuchi, Y
通讯作者：
Fukuuchi, Y
影响因子：
4.2
作者：
Murakami, A;Shigemori, T;Ohigashi, H
通讯作者：
Ohigashi, H
影响因子：
5.6
作者：
Okuyama, Satoshi;Makihata, Nahomi;Furukawa, Yoshiko
通讯作者：
Furukawa, Yoshiko
影响因子：
5.1
作者：
Yan, Huiqing;Ma, Zhaocheng;Deng, Xiuxin
通讯作者：
Deng, Xiuxin