The origin and evolution of plant cystatins and their target cysteine proteinases indicate a complex functional relationship.
The origin and evolution of plant cystatins and their target cysteine proteinases indicate a complex functional relationship.
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DOI：
10.1186/1471-2148-8-198
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发表时间：
2008-07-10
影响因子：
3.4
通讯作者：
Diaz I
中科院分区：
文献类型：
--
作者：
Martinez M;Diaz I
半胱氨酸蛋白酶C1A和C13家族在植物中起着重要的作用。比较基因组分析是获得有价值的见解的保护和进化的蛋白酶及其蛋白质抑制剂的有力工具，并可能有助于阐明这些蛋白质的功能有关的问题。我们已经进行了半胱氨酸蛋白酶C1A和C13及其推定的抑制剂在不同的分类群的代表物种的Viridiplantae的进化过程中出现的进化比较分析。结果表明，虽然C1A半胱氨酸蛋白酶存在于所有的分类组，半胱氨酸蛋白酶抑制剂和C13半胱氨酸蛋白酶是不存在的一些基础组。此外，基因重复事件已与陆地植物中获得的日益增加的结构和功能复杂性相关联。比较基因组学分析为我们提供了宝贵的见解的保护和进化的半胱氨酸蛋白酶抑制剂家族及其推定的目标，半胱氨酸蛋白酶从家庭C1A和C13。这两个家庭的蛋白质在植物中的功能必须是一个共同进化的过程，可能已经发生在进化过程中的基础和陆地植物导致它们之间的复杂的功能关系的结果。
Cystatins and their putative targets, the families of cysteine proteinases C1A and C13 play key roles in plants. Comparative genomic analyses are powerful tools to obtain valuable insights into the conservation and evolution of the proteinases and their proteinaceous inhibitors, and could aid to elucidate issues concerning the function of these proteins. We have performed an evolutionary comparative analysis of cysteine proteinases C1A and C13 and their putative inhibitors in representative species of different taxonomic groups that appeared during the evolution of the Viridiplantae. The results indicate that whereas C1A cysteine proteinases are present in all taxonomic groups, cystatins and C13 cysteine proteinases are absent in some basal groups. Moreover, gene duplication events have been associated to the increasing structural and functional complexities acquired in land plants. Comparative genomic analyses have provided us valuable insights into the conservation and evolution of the cystatin inhibitory family and their putative targets, the cysteine proteinases from families C1A and C13. Functionality of both families of proteins in plants must be the result of a coevolutionary process that might have occurred during the evolution of basal and land plants leading to a complex functional relationship among them.
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影响因子：
10.7
作者：
Castresana, J
通讯作者：
Castresana, J
影响因子：
46.9
作者：
Gutierrez-Campos, R;Torres-Acosta, JA;Gomez-Lim, MA
通讯作者：
Gomez-Lim, MA
影响因子：
7.4
作者：
Funk, V;Kositsup, B;Beers, EP
通讯作者：
Beers, EP
影响因子：
5.3
作者：
García-Lorenzo M;Sjödin A;Jansson S;Funk C
通讯作者：
Funk C
影响因子：
5.2
作者：
Hong, Joon Ki;Hwang, Jung Eun;Lim, Chae Oh
通讯作者：
Lim, Chae Oh