First case of an invasive Bacteroides dorei infection detected in a patient with a mycotic aortic aneurysm-raising a rebellion of major indigenous bacteria in humans: a case report and review.
First case of an invasive Bacteroides dorei infection detected in a patient with a mycotic aortic aneurysm-raising a rebellion of major indigenous bacteria in humans: a case report and review.
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DOI：
10.1186/s12879-021-06345-8
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发表时间：
2021-06-30
影响因子：
3.7
通讯作者：
Kawamoto S
中科院分区：
文献类型：
--
作者：
Matsuoka T;Shimizu T;Minagawa T;Hiranuma W;Takeda M;Kakuta R;Kawamoto S
多雷拟杆菌是一种厌氧革兰氏阴性细菌，于2006年首次描述。由于B. dorei和Bacteroides vulgatus，在临床实践中区分这些物种是困难的。近几十年来，16 S rRNA基因测序已成为区分分类学上接近的细菌（包括B）的补充方法。dorei和B。vulgatus，在属和种的水平。因此，B.已显示Dorei有助于某些疾病，包括1型自身免疫性糖尿病和动脉粥样硬化疾病。但目前还没有关于B引起的侵袭性传染病的报道。多雷。本报告描述了第一例直接入侵和定植人体组织的B。dorei，从而提供关于先前提出的B的应用的警告。dorei作为动脉粥样硬化疾病的活生物制剂。一名78岁的日本男性主诉间歇性胸/背痛，入院时通过增强计算机断层扫描诊断为肌层胸主动脉瘤。尽管严格的血压控制和经验性抗生素治疗，病人的病情恶化。为了防止囊肿破裂和消除感染灶，患者接受了手术治疗。切除的标本进行组织培养和16 S rRNA基因测序分析，以确定病原菌。手术后几天，培养和测序结果显示病原体为B。dorei/B. vulgatus和B. dorei，分别。患者通过适当的抗菌治疗成功治疗，并在改善后，于术后第34天转至另一家医院进行康复治疗。患者转移后未发生感染或动脉瘤复发。本报告描述了首例由B引起的侵袭性传染病。Dorei，给它作为动脉粥样硬化疾病的益生菌的应用蒙上了阴影。在线版本包含补充材料，可通过10.1186/s12879-021-06345-8获得。
Bacteroides dorei is an anaerobic gram-negative bacterium first described in 2006. Because of the high similarity in mass spectra between B. dorei and Bacteroides vulgatus, discriminating between these species is arduous in clinical practice. In recent decades, 16S rRNA gene sequencing has been a complementary method for distinguishing taxonomically close bacteria, including B. dorei and B. vulgatus, at the genus and species levels. Consequently, B. dorei has been shown to contribute to some diseases, including type 1 autoimmune diabetes mellitus and atherosclerotic diseases. However, there are no reports on invasive infectious diseases caused by B. dorei. This report describes the first case of direct invasion and colonisation of human tissue by B. dorei, thus providing a warning regarding the previously proposed application of B. dorei as a live biotherapeutic for atherosclerotic diseases. A 78-year-old Japanese man complained of intermittent chest/back pain and was diagnosed with a mycotic thoracic aortic aneurysm by enhanced computed tomography on admission. Despite strict blood pressure control and empirical antibiotic therapy, the patient’s condition worsened. To prevent aneurysmal rupture and eliminate infectious foci, the patient underwent surgical treatment. The resected specimen was subjected to tissue culture and 16S rRNA gene sequencing analysis to identify pathogenic bacteria. A few days after the surgery, culture and sequencing results revealed that the pathogen was B. dorei/B. vulgatus and B. dorei, respectively. The patient was successfully treated with appropriate antibacterial therapy and after improvement, was transferred to another hospital for rehabilitation on postoperative day 34. There was no recurrence of infection or aneurysm after the patient transfer. This report describes the first case of invasive infectious disease caused by B. dorei, casting a shadow over its utilisation as a probiotic for atherosclerotic diseases. The online version contains supplementary material available at 10.1186/s12879-021-06345-8.
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