An approximate line attractor in the hypothalamus encodes an aggressive state.
An approximate line attractor in the hypothalamus encodes an aggressive state.
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DOI：
10.1016/j.cell.2022.11.027
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发表时间：
2023-01-05
期刊：
影响因子：
64.5
通讯作者：
Kennedy, Ann
中科院分区：
文献类型：
--
作者：
Nair, Aditya;Karigo, Tomomi;Yang, Bin;Ganguli, Surya;Schnitzer, Mark J.;Linderman, Scott W.;Anderson, David J.;Kennedy, Ann
下丘脑调节天生的社会行为，包括交配和攻击。这些行为可以分别通过光遗传刺激MPOA和VMHvl内特定的神经元亚群来引起。在这里，我们执行动态系统建模人口神经元活动在这些核在社会行为。在VMHvl中，无监督分析识别出具有大时间常数（bbb50 s）的神经活动的主导维度，在神经状态空间中生成近似的线吸引子。沿着这个吸引子的神经轨迹的进展与对抗行为的升级相关，这表明它可能编码了一种可扩展的攻击状态。与此一致的是，个体在吸引子时间常数大小上的差异与攻击性的差异密切相关。相比之下，在交配过程中，MPOA没有观察到线吸引子；相反，具有快速动态的神经元被调整到特定的动作。因此，不同的下丘脑核使用不同的神经群体代码来表示相似的社会行为。不同的下丘脑区域利用不同的神经动力学来编码交配和攻击行为。
The hypothalamus regulates innate social behaviors, including mating and aggression. These behaviors can be evoked by optogenetic stimulation of specific neuronal subpopulations within MPOA and VMHvl, respectively. Here we perform dynamical systems modeling of population neuronal activity in these nuclei during social behaviors. In VMHvl, unsupervised analysis identified a dominant dimension of neural activity with a large time constant (>50s), generating an approximate line attractor in neural state space. Progression of the neural trajectory along this attractor was correlated with an escalation of agonistic behavior, suggesting that it may encode a scalable state of aggressiveness. Consistent with this, individual differences in the magnitude of the attractor time constant were strongly correlated with differences in aggressiveness. In contrast, line attractors were not observed in MPOA during mating; instead, neurons with fast dynamics were tuned to specific actions. Thus, different hypothalamic nuclei employ distinct neural population codes to represent similar social behaviors. Different hypothalamic regions utilize distinct neural dynamics to encode mating and aggressive behaviors.
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