A green, efficient and precise hydrogen therapy of cancer based on in vivo electrochemistry.
A green, efficient and precise hydrogen therapy of cancer based on in vivo electrochemistry.
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基于体内电化学的绿色、高效、精准的癌症氢疗法
DOI：
10.1093/nsr/nwz199
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发表时间：
2020-03
影响因子：
20.6
通讯作者：
Jin Y
中科院分区：
文献类型：
--
作者：
Qi G;Wang B;Song X;Li H;Jin Y
摘要 通过结合中国传统针灸铁针电极和体内电化学技术，我们首次实现了肿瘤体内可控产氢，并首次将其用于肿瘤的有效、绿色治疗。阴极针灸电极在约3V的外加电压下工作（对活体的损害最小），在酸性肿瘤区域发生有效的电化学反应，局部产生足够的氢气，导致癌细胞破裂和死亡。由于穿刺定位、酸性肿瘤微环境和气体扩散效应，所开发的氢气产生电化学疗法（H2-ECT）策略能够实现精确和大规模的肿瘤治疗，正如对患病小鼠（神经胶质瘤和乳腺癌）的体内治疗所证明的那样。这种绿色H2-ECT简单、高效、微创，不需要昂贵的医疗设备或纳米材料和药物，因此具有非常广阔的临床应用前景。
Abstract By combined use of traditional Chinese acupuncture Fe needle electrode and in vivo electrochemistry, we achieved in vivo H2 generation in tumors in a controllable manner and exploited it for effective and green therapy of tumors for the first time. The cathodic acupuncture electrodes working under an applied voltage of ∼3 V (with minimal damage to the living body) undergo effective electrochemical reactions in the acidic tumor area that produce sufficient H2 locally to cause cancer cells to burst and die. Due to puncture positioning, the acidic tumor microenvironment and gas diffusion effect, the developed H2 generation electrochemotherapy (H2-ECT) strategy enables precise and large-scale tumor therapy, as demonstrated by in vivo treatment of diseased mice (glioma and breast cancers). Such green H2-ECT is simple, highly efficient and minimally invasive, requiring no expensive medical equipment or nano materials and medication, and is therefore very promising for potential clinical applications.
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DOI：
10.3322/caac.20114
发表时间：
2011-07
期刊：
CA: a cancer journal for clinicians
影响因子：
--
作者：
Agostinis P;Berg K;Cengel KA;Foster TH;Girotti AW;Gollnick SO;Hahn SM;Hamblin MR;Juzeniene A;Kessel D;Korbelik M;Moan J;Mroz P;Nowis D;Piette J;Wilson BC;Golab J
通讯作者：
Golab J
影响因子：
3.9
作者：
KEDDAM, M;MATTOS, OR;TAKENOUTI, H
通讯作者：
TAKENOUTI, H
影响因子：
64.8
作者：
Mellman, Ira;Coukos, George;Dranoff, Glenn
通讯作者：
Dranoff, Glenn
影响因子：
254.7
作者：
Parkin, DM;Bray, F;Pisani, P
通讯作者：
Pisani, P
影响因子：
8.4
作者：
Hirayama, Tasuku;Okuda, Kensuke;Nagasawa, Hideko
通讯作者：
Nagasawa, Hideko