Spatial reconstruction by patients with hippocampal damage is dominated by relational memory errors.
Spatial reconstruction by patients with hippocampal damage is dominated by relational memory errors.
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DOI：
10.1002/hipo.22115
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发表时间：
2013-07
期刊：
影响因子：
3.5
通讯作者：
Cohen, Neal J.
中科院分区：
文献类型：
--
作者：
Watson, Patrick D.;Voss, Joel L.;Warren, David E.;Tranel, Daniel;Cohen, Neal J.
海马体损伤在不同的刺激类型和测试格式中引起深刻而有限的记忆损伤。在这里，在涉及单一类别刺激的单一测试格式中，我们确定了不同的表现错误，以更好地表征潜在缺陷的细节。这项任务涉及研究和重建对象数组在短暂的保留间隔。海马体损伤患者表现出的最显著特征是，他们倾向于在任何大小的数组中颠倒成对物品的相对位置，有效地“交换”成对物品。这些“交换错误”是健忘症的主要错误类型，几乎从未在健康的比较参与者中发生过，而且实际上导致了在更传统的指标（如研究位置和重建位置之间的距离）上表现不佳。即使在只涉及一对物体的试验中，患者也会出现交换错误。这种特殊缺陷的选择性和严重性给记忆和海马体理论带来了严峻的挑战。
Hippocampal damage causes profound yet circumscribed memory impairment across diverse stimulus types and testing formats. Here, within a single test format involving a single class of stimuli, we identified different performance errors to better characterize the specifics of the underlying deficit. The task involved study and reconstruction of object arrays across brief retention intervals. The most striking feature of patients’ with hippocampal damage performance was that they tended to reverse the relative positions of item pairs within arrays of any size, effectively “swapping” pairs of objects. These “swap errors” were the primary error type in amnesia, almost never occurred in healthy comparison participants, and actually contributed to poor performance on more traditional metrics (such as distance between studied and reconstructed location). Patients made swap errors even in trials involving only a single pair of objects. The selectivity and severity of this particular deficit creates serious challenges for theories of memory and hippocampus.
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影响因子：
2.9
作者：
Damasio, Antonio R.
通讯作者：
Damasio, Antonio R.
DOI：
10.1080/13803390590949287
发表时间：
2006-05-01
影响因子：
2.2
作者：
Allen, JS;Tranel, D;Damasio, H
通讯作者：
Damasio, H
海马健忘症会损害各种关系记忆。
影响因子：
2.9
作者：
Konkel, Alex;Warren, David E.;Duff, Melissa C.;Tranel, Daniel N.;Cohen, Neal J.
通讯作者：
Cohen, Neal J.
影响因子：
56.9
作者：
COHEN, NJ;SQUIRE, LR
通讯作者：
SQUIRE, LR
影响因子：
3.2
作者：
Hannula, Deborah E.;Ryan, Jennifer D.;Cohen, Neal J.
通讯作者：
Cohen, Neal J.