Hippocampal amnesia impairs all manner of relational memory.
Hippocampal amnesia impairs all manner of relational memory.
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海马健忘症会损害各种关系记忆。
DOI：
10.3389/neuro.09.015.2008
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发表时间：
2008
影响因子：
2.9
通讯作者：
Cohen, Neal J.
中科院分区：
文献类型：
--
作者：
Konkel, Alex;Warren, David E.;Duff, Melissa C.;Tranel, Daniel N.;Cohen, Neal J.
关系记忆理论认为，海马体支持各种关系的记忆，而海马体损伤后的健忘症则会削弱这种记忆。不幸的是，许多关于海马体依赖性记忆的研究要么只研究了一种类型的关系记忆，要么合并了多种关系。这里报道的实验采用了一种程序，在这种程序中，几种关系记忆（空间记忆、联想记忆和顺序记忆）中的每一种都可以使用相同的材料单独测试。实验1对内侧颞叶（MTL）损伤的健忘症患者的三种关系和项目记忆进行评估。与匹配的比较参与者相比，健忘症患者在所有三个相关任务上的表现都受到损害。但对于那些MTL损伤仅限于海马体的患者，与关系记忆相比，项目记忆的表现相对保留，尽管仍低于比较参与者。在实验2中，比较参与者的研究暴露减少，使他们的项目记忆与实验1中的失忆症患者相匹配。对比对象的关系记忆表现远高于健忘症患者的水平，这表明所有三种关系记忆表现对海马体完整性的不成比例的依赖。对比参与者和大学年龄参与者的各种任务表现的相关分析表明，我们对项目记忆的测量不受项目之间关联记忆的显著影响。
Relational memory theory holds that the hippocampus supports, and amnesia following hippocampal damage impairs, memory for all manner of relations. Unfortunately, many studies of hippocampal-dependent memory have either examined only a single type of relational memory or conflated multiple kinds of relations. The experiments reported here employed a procedure in which each of several kinds of relational memory (spatial, associative, and sequential) could be tested separately using the same materials. In Experiment 1, performance of amnesic patients with medial temporal lobe (MTL) damage was assessed on memory for the three types of relations as well as for items. Compared to the performance of matched comparison participants, amnesic patients were impaired on all three relational tasks. But for those patients whose MTL damage was limited to the hippocampus, performance was relatively preserved on item memory as compared to relational memory, although still lower than that of comparison participants. In Experiment 2, study exposure was reduced for comparison participants, matching their item memory to the amnesic patients in Experiment 1. Relational memory performance of comparison subjects was well above amnesic patient levels, showing the disproportionate dependence of all three relational memory performances on the integrity of the hippocampus. Correlational analyses of the various task performances of comparison participants and of college-age participants showed that our measures of item memory were not influenced significantly by memory for associations among the items.
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DOI：
10.1080/13803390590949287
发表时间：
2006-05-01
影响因子：
2.2
作者：
Allen, JS;Tranel, D;Damasio, H
通讯作者：
Damasio, H
DOI：
10.1073/pnas.94.13.7109
发表时间：
1997-06-24
影响因子：
11.1
作者：
Dusek, JA;Eichenbaum, H
通讯作者：
Eichenbaum, H
影响因子：
3.5
作者：
Crane, J;Milner, B
通讯作者：
Milner, B
影响因子：
2.5
作者：
Davachi, L;Wagner, AD
通讯作者：
Wagner, AD
影响因子：
1.9
作者：
Dusek, JA;Eichenbaum, H
通讯作者：
Eichenbaum, H